Germ-line MTHFR C677T, FV H1299R and PAI-1 5G/4G Variations in Breast Carcinoma

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dc.contributor.authorOzen, Filiz
dc.contributor.authorErdis, Eda
dc.contributor.authorSik, Ebru
dc.contributor.authorSılan, Fatma
dc.contributor.authorUludağ, Ahmet
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-01-27T20:17:10Z
dc.date.available2025-01-27T20:17:10Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Various oncogenes related to cancer have been extensively studied and several polymorphisms have been found to be associated with breast cancer. The current report outlines analysis of germ-line polymorphisms for C677T, A1298C (MTHFR), Leiden, R2 (FV) and 5G/4G (PAI-1) in Turkish breast cancer patients. We studied 51 cases diagnosed with invasive ductal and operable with lymph node-positive breast cancer and 106 women as a control group. Materials and Methods: Peripheric blood-DNA samples were used for genotyping by StripAssay technique which is based on the reverse-hybridization principle and real-time PCR methods and results were compared statistically. Results: The frequency of the MTHFR gene 677T and 1298A alleles were significantly higher in cancer patients than in the healthy subjects. The T allele frequency in codon 677 was 2.3-fold and C allele frequency was 3.1-fold increased in BC when compared to the control group for the MTHFR gene. Both differences were statistically significant (OR: 2.295, CI: 1.283-4.106), p<0.006 and (OR: 3.131, CI: 1.826-5.369), p<0.0001 respectively. The R2 allele frequency of FV gene was 5.1-fold increased in the current BC when compared to the control group and that difference was also statistically significant (OR: 5.133, CI: 1.299-20.28), p<0.02. Conclusions: The present data suggest that germ-line polymorphisms of C677T, C1298A for MTHFR and R2 for FV are associated in breast cancer and may be additional prognostic markers related to breast cancer survival. The results now need to be confirmed in a larger group of patients.
dc.identifier.doi10.7314/APJCP.2013.14.5.2903
dc.identifier.endpage2908
dc.identifier.issn1513-7368
dc.identifier.issue5
dc.identifier.pmid23803051
dc.identifier.scopus2-s2.0-84880362023
dc.identifier.scopusqualityQ3
dc.identifier.startpage2903
dc.identifier.urihttps://doi.org/10.7314/APJCP.2013.14.5.2903
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21505
dc.identifier.volume14
dc.identifier.wosWOS:000331473400036
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAsian Pacific Organization Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectMTHFR C677T and A1298C
dc.subjectFV Leiden and R2
dc.subjectPAI-1 5G/4G
dc.subjectSNPs
dc.subjectbreast carcinoma
dc.titleGerm-line MTHFR C677T, FV H1299R and PAI-1 5G/4G Variations in Breast Carcinoma
dc.typeArticle

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