Thiol-disulphide Homeostasis in Patients with Schizophrenia: The Potential Biomarkers of Oxidative Stress in Acute Exacerbation of Schizophrenia

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dc.authorid0000-0002-0684-3303en_US
dc.authorscopusid57189906530en_US
dc.authorwosidHLG-6687-2023en_US
dc.contributor.authorKorkmaz, Şükrü Alperen
dc.contributor.authorUlusoy Kaymak, Semra
dc.contributor.authorNeşelioğlu, Salim
dc.contributor.authorErel, Özcan
dc.date.accessioned2024-02-21T06:14:07Z
dc.date.available2024-02-21T06:14:07Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjective: : Recent evidence suggests that oxidative stress contributes to the pathophysiology of schizophrenia. This study aimed to compare thiol-disulphide homeostasis in acute and stable phases of schizophrenia for the first time. Methods: : Among the patients with schizophrenia, 61 in the acute-phase and 61 in the stable phase of their illness were enrolled in the study. Native thiol (NT), total thiol (TT), disulphide (SS), disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol for thiol-disulphide homeostasis were compared between the groups. The Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive/Negative Symptoms (SAPS/SANS), Clinical Global Impression-Severity Scale (CGI-S), Barnes Akathisia Rating Scale, and Simpson-Angus Scale were used to assess symptoms. Results: : After controlling for age, sex, body mass index, and smoking status there were significant differences in NT, TT, SS/NT, SS/TT, and NT/TT, but not SS. Thiol/disulphide homeostasis has shifted in favour of the oxidative side in patients with acute-phase compared to that in stable schizophrenia. BPRS, SAPS, and CGI-S scores were significantly correlated with all six thiol-disulphide parameters, but not SANS, when controlling for age and sex. Significant receiver operating characteristic (ROC) curves were obtained for all thiol-disulphide homeostasis parameters. Discriminant analysis was found to be statistically significant in discriminating between groups. Conclusion: : These results show that oxidative status increases thiol-disulphide homeostasis in patients with acute-phase schizophrenia compared to those with stable schizophrenia. These findings suggest that thiol-disulphide parameters can be used as biomarkers for the acute exacerbation of schizophrenia.en_US
dc.identifier.citationKorkmaz, Ş.A., Ulusoy Kaymak, S., Neşelioğlu, S., & Erel, Ö. (2024) Thiol-disulphide Homeostasis in Patients with Schizophrenia: The Potential Biomarkers of Oxidative Stress in Acute Exacerbation of Schizophrenia. Clinical Psychopharmacology and Neuroscience, 22(1), 139-150. doi: 10.9758/cpn.23.1084en_US
dc.identifier.doi10.9758/cpn.23.1084
dc.identifier.endpage150en_US
dc.identifier.issn1738-1088
dc.identifier.issn2093-4327
dc.identifier.issue1en_US
dc.identifier.pmid38247420
dc.identifier.scopus2-s2.0-85192260848
dc.identifier.startpage139en_US
dc.identifier.urihttps://doi.org/10.9758/cpn.23.1084
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5706
dc.identifier.volume22en_US
dc.identifier.wosWOS:001166001400001
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorKorkmaz, Şükrü Alperen
dc.language.isoen
dc.publisherKorean College of Neuropsychopharmacologyen_US
dc.relation.ispartofClinical Psychopharmacology and Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectBiomarkersen_US
dc.subjectDisulfideen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.subjectSchizophreniaen_US
dc.subjectThiolen_US
dc.titleThiol-disulphide Homeostasis in Patients with Schizophrenia: The Potential Biomarkers of Oxidative Stress in Acute Exacerbation of Schizophrenia
dc.typeArticle

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