A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression

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dc.authoridyalin, nefize/0000-0003-4298-5074
dc.authoridAydemir, Omer/0000-0003-3050-1263
dc.authoridOZERDEM, AYSEGUL/0000-0002-9455-5896
dc.contributor.authorAltinbas, Kursat
dc.contributor.authorOzerdem, Aysegul
dc.contributor.authorPrieto, Miguel L.
dc.contributor.authorFuentes, Manuel E.
dc.contributor.authorYalin, Nefize
dc.contributor.authorErsoy, Zeliha
dc.contributor.authorAydemir, Omer
dc.date.accessioned2025-01-27T20:45:47Z
dc.date.available2025-01-27T20:45:47Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods: The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (IAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BR Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results: There was no significant difference between mood groups in the mean rnHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations: Small sample size and cross-sectional design. Conclusion: Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments. (C) 2013 Published by Elsevier B.V.
dc.description.sponsorshipMayo Foundation
dc.description.sponsorshipMayo Foundation.
dc.identifier.doi10.1016/j.jad.2013.07.032
dc.identifier.endpage482
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.pmid24070907
dc.identifier.scopus2-s2.0-84889100550
dc.identifier.scopusqualityQ1
dc.identifier.startpage478
dc.identifier.urihttps://doi.org/10.1016/j.jad.2013.07.032
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24717
dc.identifier.volume152
dc.identifier.wosWOS:000327763600068
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal of Affective Disorders
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectModified hypomania checklist
dc.subjectBipolar
dc.subjectUnipolar
dc.subjectDepression
dc.titleA multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression
dc.typeArticle

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