The role of paraoxonase and myeloperoxidase as oxidative stress markers in pregnant women with hypothyroidism

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dc.authoridCAKINA, SUAT/0000-0002-3990-7641
dc.contributor.authorCakina, Suat
dc.contributor.authorPek, Eren
dc.contributor.authorOzkavak, Onur
dc.contributor.authorKocyigit, Deniz
dc.contributor.authorBeyazit, Fatma
dc.date.accessioned2025-01-27T21:02:00Z
dc.date.available2025-01-27T21:02:00Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: This study aims to measure paraoxonase 1 (PON 1) and myeloperoxidase (MPO) levels in patients diagnosed with hypothyroidism during pregnancy by spectrophotometric method and to compare the results with healthy controls. Methods: For the study, the blood samples of 45 hypothyroid pregnant patients and 45 healthy control pregnant individuals who were compatible with the patient group in terms of age were taken. PON 1 and MPO levels in both groups were measured using spectrophotometric methods and statistical analysis was performed. Results: Serum PON 1 activity levels were significantly lower in hypothyroid pregnant patients than in the control group (p=.020). The patients group had significantly higher serum MPO concentrations than in control group (p=.020). MPO/PON-1 ratio was higher in pregnant patients with hypothyroidism than in the control group (p=.030). Conclusion: Decreased levels of PON1 with increased levels of MPO in hypothyroid pregnant patients suggest the critical role of oxidative stress in hypothyroidism during pregnancy.
dc.identifier.doi10.1080/09513590.2022.2114449
dc.identifier.endpage843
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue10
dc.identifier.pmid35999709
dc.identifier.scopus2-s2.0-85136585774
dc.identifier.scopusqualityQ2
dc.identifier.startpage840
dc.identifier.urihttps://doi.org/10.1080/09513590.2022.2114449
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27255
dc.identifier.volume38
dc.identifier.wosWOS:000844088400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjecthypothyroidism
dc.subjectpregnancy
dc.subjectparaoxonase
dc.subjectmyeloperoxidase
dc.titleThe role of paraoxonase and myeloperoxidase as oxidative stress markers in pregnant women with hypothyroidism
dc.typeArticle

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