Effects of boric acid on the healing of Achilles tendons of rats

Basit Öğe Kaydı
dc.authoridkaymaz, burak/0000-0001-6207-8063
dc.contributor.authorKaymaz, Burak
dc.contributor.authorGolge, Umut Hatay
dc.contributor.authorOzyalvach, Gulzade
dc.contributor.authorKomurcu, Erkam
dc.contributor.authorGoksel, Ferdi
dc.contributor.authorMermerkaya, Musa Ugur
dc.contributor.authorDoral, Mahmut Nedim
dc.date.accessioned2025-01-27T20:24:52Z
dc.date.available2025-01-27T20:24:52Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractTendinous lesions are among the most frequent pathologies encountered in sportsmen. The objectives of new treatments are to improve the healing process and reduce the recovery time. Boron plays an important role in the wound repair process by increasing components of extracellular matrix and angiogenesis. This animal study aimed to investigate the effect of boric acid on healing of the Achilles tendon. The right Achilles tendons of 40 rats were completely sectioned, and the rats were randomly divided into five groups. Each group consisted of eight rats. Groups 1 and 2 were oral boric acid groups with the doses of 4 and 8 mg/kg/day boric acid, respectively. Group 3 was the local boric acid group (8 mg/kg boric acid intratendinous injection). Group 4 was administered both oral and local boric acid (8 mg/kg/day orally and 8 mg/kg boric acid intratendinous injection), and group 5 was the control group with no boric acid application. At the end of the fourth week, all the rats were killed and histopathological examination of the Achilles tendon repair site was made. Histopathological examination of the tissue sections revealed more properly oriented collagen fibres, more normal cellular distribution of tenocytes and more properly organized vascular bundles in group 1 and group 2, which were the groups administered oral boric acid. Pathological sum scores of groups 1 and 2 were less than those of the other groups, and the differences between the oral boric acid groups (group 1 and group 2) and the other three groups (groups 3, 4 and 5) were statistically significant (p = 0.001). As boric acid is safe and toxicity even after very high doses is unusual, oral boric acid may be used as an agent to improve the healing process of tendon injuries. However, biomechanical tests should also be performed to show the effect of boric acid on strength and endurance of the tendon before it can be used in clinical practice.
dc.identifier.doi10.1007/s00167-015-3617-5
dc.identifier.endpage3744
dc.identifier.issn0942-2056
dc.identifier.issn1433-7347
dc.identifier.issue12
dc.identifier.pmid25931129
dc.identifier.scopus2-s2.0-84928689831
dc.identifier.scopusqualityQ1
dc.identifier.startpage3738
dc.identifier.urihttps://doi.org/10.1007/s00167-015-3617-5
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22368
dc.identifier.volume24
dc.identifier.wosWOS:000389607500007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofKnee Surgery Sports Traumatology Arthroscopy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBoric acid
dc.subjectAchilles tendon
dc.subjectTendon healing
dc.subjectRats
dc.subjectCollagen fibres
dc.subjectAngiogenesis
dc.titleEffects of boric acid on the healing of Achilles tendons of rats
dc.typeArticle

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