CTLA4+rs231775 gene polymorphism increases PCOS, regardless of the levels of interleukin-6 and tumor necrosis factor-? in the serum

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dc.contributor.authorBeyazit, Fatma
dc.contributor.authorCicekliyurt, Meliha Merve
dc.contributor.authorTurkon, Hakan
dc.contributor.authorUnsal, Mesut Abdulkerim
dc.contributor.authorPek, Eren
dc.date.accessioned2025-01-27T20:38:59Z
dc.date.available2025-01-27T20:38:59Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Polycystic ovarian syndrome (PCOS) is a long-standing inflammation-related disease with increased levels of circulating pro-inflammatory markers. By affecting inflammatory cytokine production, cytotoxic T lymphocyte-associated antigen (CTLA-4) polymorphism can alter the immune system and trigger distinct disease states. The aim of the study was to investigate if CTLA4 polymorphism is associated with PCOS, and if so, (2) whether this situation influences serum interleukin-6 (IL-6) and TNF-alpha in PCOS.Material and Methods: CTLA4+rs231775 gene polymorphism with IL-6 and TNF-a levels were determined in 92 PCOS women and 88 healthy controls. Study groups were further subdivided according to body mass index (BMI) and the degree of insulin resistance (IR), and comparisons were made within each study group.Results: The prevalence of the A allele of single nucleotide polymorphism (SNP) rs231775 was more frequent in PCOS women compared with healthy controls [OR: 1.99, 95% CI:1.273-3.107, p =0.0023]. The heterozygous genotype was also shown to be strongly associated with PCOS development [OR: 3.041, 95%CI:1.604-5.766, p=0.0005]. Although TNF-a levels of PCOS patients were detected to be elevated, no difference was found in the study groups with respect to serum IL-6 levels. In addition, no association was observed between CTLA4+rs231775 polymorphism and serum pro-inflammatory cytokine levels.Discussion: The present study demonstrates for the first time that CTLA4+rs231775 gene polymorphism increases susceptibility to PCOS 2 times more in the case of A allele carriage and 3 times more in heterozygous individuals, independent from the long-standing low-grade inflammatory disease state encountered in patients with PCOS.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University [THD-2017-1208]
dc.description.sponsorshipFunding: This research is supported by The Scientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University (Project ID: THD-2017-1208) .
dc.identifier.doi10.4328/ACAM.21638
dc.identifier.endpage701
dc.identifier.issn2667-663X
dc.identifier.issue8
dc.identifier.startpage696
dc.identifier.urihttps://doi.org/10.4328/ACAM.21638
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23825
dc.identifier.volume14
dc.identifier.wosWOS:001050540900007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPolycystic Ovary Syndrome
dc.subjectCTLA4
dc.subjectTNF-& alpha;
dc.subjectIL-6
dc.subjectPolymorphism
dc.titleCTLA4+rs231775 gene polymorphism increases PCOS, regardless of the levels of interleukin-6 and tumor necrosis factor-? in the serum
dc.typeArticle

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