Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties

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dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.contributor.authorBozkurt, Aras Adem
dc.contributor.authorMustafa, Guven
dc.contributor.authorTarik, Akman
dc.contributor.authorAdile, Ozkan
dc.contributor.authorMurat, Sen Halil
dc.contributor.authorMesut, Kilicoglu
dc.contributor.authorYilduay, Kalkan
dc.date.accessioned2025-01-27T21:00:07Z
dc.date.available2025-01-27T21:00:07Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThere are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondiadehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and -9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These findings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis.
dc.identifier.doi10.4103/1673-5374.145353
dc.identifier.endpage1890
dc.identifier.issn1673-5374
dc.identifier.issue21
dc.identifier.pmid25558237
dc.identifier.scopus2-s2.0-84916626644
dc.identifier.scopusqualityQ1
dc.identifier.startpage1884
dc.identifier.urihttps://doi.org/10.4103/1673-5374.145353
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26943
dc.identifier.volume9
dc.identifier.wosWOS:000346324900008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherShenyang Editorial Dept Neural Regeneration Res
dc.relation.ispartofNeural Regeneration Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectnerve regeneration
dc.subjectsyringaldehyde
dc.subjectbrain ischemia
dc.subjectneuroprotective effects
dc.subjectinflammatory
dc.subjectoxidative stress
dc.subjectapoptosis
dc.subjectneural regeneration
dc.titleSyringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties
dc.typeArticle

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