Mean platelet volume and platelet distribution width can be related to bone mineralization

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dc.contributor.authorAkbal, A.
dc.contributor.authorGokmen, F.
dc.contributor.authorGencer, M.
dc.contributor.authorInceer, B. S.
dc.contributor.authorKomurcu, E.
dc.date.accessioned2025-01-27T20:49:36Z
dc.date.available2025-01-27T20:49:36Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPlatelets functions are related to bone resorption and formation. The present study aimed at studying the association between platelet function and bone mineralization. We showed that mean platelet volume (MPV) and platelet distribution width (PDW) levels in osteoporosis patients increased. The study also showed that PDW and age independently associated with bone mineralization. MPV and PDW are widely used for assessing platelet function. Recently, authors argued that platelet function has an important role in bone mineralization. However, only one study has investigated the relationship between MPV and osteoporosis. We aimed to study the levels of MPV and PDW in postmenopausal osteoporosis. We investigated 320 bone mineral density (BMD) measurements between the years 2012 and 2013 retrospectively in our clinic. Eighty patients whom chronic diseases are absent and all laboratory findings are complete enrolled in this study. Patients were divided in three groups as an osteoporosis, osteopenia, and normal BMD group. MPV and PDW levels were investigated in these groups. We performed correlation test and linear regression analysis to determine whether there is a relationship between platelet function markers and BMD measurements. Eighty patients were divided as an osteoporosis, osteopenia, and normal BMD group. MPV levels and PDW levels in the osteoporosis group were lower than the normal BMD group. PDW was positively correlated with femur total T (FTT) score and lumbar 1-4T (L1-4T) scores. Linear regression analysis showed that age and PDW were independently related to FTT and LTT scores. Platelet functions are related to the bone mineralization. PDW and MPV have a significant role in the development of postmenopausal osteoporosis.
dc.identifier.doi10.1007/s00198-014-2764-8
dc.identifier.endpage2295
dc.identifier.issn0937-941X
dc.identifier.issn1433-2965
dc.identifier.issue9
dc.identifier.pmid24923794
dc.identifier.scopus2-s2.0-84906307138
dc.identifier.scopusqualityQ1
dc.identifier.startpage2291
dc.identifier.urihttps://doi.org/10.1007/s00198-014-2764-8
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25239
dc.identifier.volume25
dc.identifier.wosWOS:000340675200016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer London Ltd
dc.relation.ispartofOsteoporosis International
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMean platelet volume
dc.subjectOsteoporosis
dc.subjectPlatelet distribution width
dc.titleMean platelet volume and platelet distribution width can be related to bone mineralization
dc.typeArticle

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