Prevention of rocuronium induced mast cell activation with prophylactic oleuropein rich diet in anesthetized rabbits

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dc.authoridAltinisik, Hatice Betul/0000-0001-9273-0876
dc.contributor.authorSimsek, Tuncer
dc.contributor.authorErbas, Mesut
dc.contributor.authorBuyuk, Basak
dc.contributor.authorPala, Cigdem
dc.contributor.authorSahin, Hasan
dc.contributor.authorAltinisik, Betul
dc.date.accessioned2025-01-27T20:58:13Z
dc.date.available2025-01-27T20:58:13Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: The effect of a prophylactic oleuropein-rich diet before anesthesia accompanied by the widely-used steroid-based neuromuscular drug rocuronium on mast cell activation was investigated in the study. Methods: 14 rabbits used in the study. The rabbits in the oleuropein group were given oleuropein-rich extract added to the animals' water at doses of 20 mg/kg oleuropein for 15 days orally. After 15 days, all rabbits in the two groups were given general anesthesia with rocuronium of 1 mg/kg. After 1 day, animals were sacrificed and the liver tissue sections stained with H&E, toluidine blue and tryptase for immunohistochemical study. Results: There was no statistically significant difference between ALT, AST and albumin averages of the oleuropein and control groups (p>0.05). The tryptase average of the control group was higher than the tryptase average of the oleuropein group and this difference was statistically significant (p=0.003). The T. blue average in the oleuropein group was higher than the control group. However, there was no statistically significant difference between groups (p=0.482). Conclusions: Rocuronium adverse effects, like hypersensitivity and anaphylaxis, may limit routine use of this substance. The use of oleuropein reduced the number of inflammatory cells and prevented degranulation.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Unit
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Unit
dc.identifier.doi10.1590/s0102-865020180110000002
dc.identifier.endpage963
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue11
dc.identifier.pmid30517322
dc.identifier.scopus2-s2.0-85059828854
dc.identifier.scopusqualityQ2
dc.identifier.startpage954
dc.identifier.urihttps://doi.org/10.1590/s0102-865020180110000002
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26642
dc.identifier.volume33
dc.identifier.wosWOS:000451928400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAnesthesia
dc.subjectMast Cells
dc.subjectRabbits
dc.titlePrevention of rocuronium induced mast cell activation with prophylactic oleuropein rich diet in anesthetized rabbits
dc.typeArticle

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