Reduction Behavior of Moxifloxacin Hydrocholaride and Its Analysis in Spiked Human Urine and Dosage Form by Voltammetry

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dc.contributor.authorTepeli, Burcu
dc.contributor.authorYılmaz, Selehattin
dc.contributor.authorYağmur, Sultan
dc.date.accessioned2025-01-27T19:20:36Z
dc.date.available2025-01-27T19:20:36Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAvoltammetric method was developed to analyze moxifloxacin hydrochloride (Mox- HCl) in pharmaceutical preparations and spiked human urine. The experimental measurements were completed using different buffer systems (pH 0.50- 12.05) on Glassy Carbon Electrode (GCE) with differential pulse voltammetry (DPV) and Cyclic Voltammetry (CV) methods. The effect of pH on the peak current and potential were determined. Britton-Robinson (BR) buffer (pH 7.00) was used for analysis. The peak was established to be diffusion-controlled based on the nature of electrode. Calibration plots were prepared for the concentration range from 3×10-4 M to 1.1×10-3 M with DPV. Limits of detection (LOD) and quantification (LOQ) were calculated as 5.1×10-5 M and 2.30×10-4 M, respectively. The validation of the applied methods was completed. Electroreduction mechanism was proposed.
dc.identifier.doi10.17350/HJSE19030000141
dc.identifier.endpage156
dc.identifier.issn2149-2123
dc.identifier.issn2148-4171
dc.identifier.issue2
dc.identifier.startpage153
dc.identifier.trdizinid1119879
dc.identifier.urihttps://doi.org/10.17350/HJSE19030000141
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1119879
dc.identifier.urihttps://hdl.handle.net/20.500.12428/14953
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofHittite Journal of Science and Engineering
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectKimya
dc.subjectTıbbi
dc.subjectFarmakoloji ve Eczacılık
dc.titleReduction Behavior of Moxifloxacin Hydrocholaride and Its Analysis in Spiked Human Urine and Dosage Form by Voltammetry
dc.typeArticle

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