Protective effect of syringic acid on kidney ischemia-reperfusion injury

Basit Öğe Kaydı
dc.authoridsilan, coskun/0000-0002-8352-6571
dc.authoridAkbas, Alpaslan/0000-0003-1470-5952
dc.contributor.authorSancak, Eyup Burak
dc.contributor.authorAkbas, Alpaslan
dc.contributor.authorSilan, Coskun
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorTurkon, Hakan
dc.contributor.authorOzkanli, Sidika Seyma
dc.date.accessioned2025-01-27T20:41:02Z
dc.date.available2025-01-27T20:41:02Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe objective of the present study was to determine whether preischemic administration of syringic acid (SA) would attenuate renal ischemia-reperfusion injury (IRI). Rats were divided into three groups: Sham group; IR group; and IR + SA group. The effects of SA were examined using biochemical parameters including serum ischemia-modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), tissue superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and malondialdehyde (MDA). The apoptosis status and histopathological changes were evaluated. After calculating the score for each histopathological change, the total score was obtained by summing all the scores. In the SA group, MDA, IMA, TOS, and OSI decreased significantly compared to the IR group. After SA administration, the increase in GPx activity was found to be significant. Apoptosis decreased significantly in the SA group compared with the IR group. The total score significantly decreased after administration of SA. Taken together, our findings suggest that SA preconditioning is effective in reducing tissue damage induced in kidney IRI. Renal histology also showed convincing evidence regarding the protective nature of SA.
dc.identifier.doi10.3109/0886022X.2016.1149868
dc.identifier.endpage635
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue4
dc.identifier.pmid26915396
dc.identifier.scopus2-s2.0-84959244236
dc.identifier.scopusqualityQ2
dc.identifier.startpage629
dc.identifier.urihttps://doi.org/10.3109/0886022X.2016.1149868
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23982
dc.identifier.volume38
dc.identifier.wosWOS:000372164000020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectsyringic acid
dc.subjectantioxidant
dc.subjectAntiapoptotic
dc.subjectrenal ischemia reperfusion
dc.subjectoxidative stress
dc.titleProtective effect of syringic acid on kidney ischemia-reperfusion injury
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu