The protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortex

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dc.authoridSongur, Ahmet/0000-0002-6683-5495
dc.authoridMollaoglu, Hakan/0000-0002-6523-5607
dc.contributor.authorEser, Olcay
dc.contributor.authorSongur, Ahmet
dc.contributor.authorYaman, Mehmet
dc.contributor.authorCosar, Murat
dc.contributor.authorFidan, Huseyin
dc.contributor.authorSahin, Onder
dc.contributor.authorMollaoglu, Hakan
dc.date.accessioned2025-01-27T20:41:03Z
dc.date.available2025-01-27T20:41:03Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObject. We investigated the protective effects of avocado/soybean unsaponifiables (ASU) on the prefrontal cortex (PFC) after global brain ischemia/reperfusion (I/R) injury in rats. Methods. Rats were randomly divided into three experimental groups as follows: Group I was control rats, Group II was ischemia rats, Group III was Isch+ASU rats. Brain ischemia was produced via four-vessel occlusion model. These processes followed by reperfusion for 30 min for both II and III groups. Rats were sacrificed and their brains were removed immediately. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in left PFC, levels of TNF-alpha concentration were measured in the plasma. The number of apoptotic neurons was assayed in histological samples of the right PFC. Results. MDA and TNF-alpha levels as well as the number of apoptotic neurons were observed to have decreased significantly in Group III compared to Group II, while SOD activities have been found to have increased significantly in Group III in comparison to Group II, significantly. Conclusions. We think that ASU might have an antioxidant and neuroprotective effects in brain I/R injured rats.
dc.description.sponsorshipKocatepe University Scientific Research Committee [051.TIP.14]
dc.description.sponsorshipThis study was supported by the Kocatepe University Scientific Research Committee (Project no. 051.TIP.14). The authors alone are responsible for the content and writing of the paper.
dc.identifier.doi10.3109/02688697.2010.520767
dc.identifier.endpage706
dc.identifier.issn0268-8697
dc.identifier.issn1360-046X
dc.identifier.issue6
dc.identifier.pmid20874457
dc.identifier.scopus2-s2.0-82355195023
dc.identifier.scopusqualityQ2
dc.identifier.startpage701
dc.identifier.urihttps://doi.org/10.3109/02688697.2010.520767
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23990
dc.identifier.volume25
dc.identifier.wosWOS:000297337800008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBritish Journal of Neurosurgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAvocado/soybean unsaponifiables
dc.subjectbrain ischemia/reperfusion
dc.subjectprefrontal cortex
dc.titleThe protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortex
dc.typeArticle

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