Serum estradiol/free testosterone ratio can be important predictor for varicose vein recurrence in men

Basit Öğe Kaydı
dc.contributor.authorOzcan, S.
dc.contributor.authorTezcan, O.
dc.contributor.authorKurt, T.
dc.contributor.authorTurkone, H.
dc.contributor.authorKarahan, O.
dc.contributor.authorCaliskan, A. T.
dc.contributor.authorAdam, G.
dc.date.accessioned2025-01-27T21:01:30Z
dc.date.available2025-01-27T21:01:30Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim. Recurrent varicose veins are a frustration for both the patient and the surgeon. More investigation of the exact diagnosis, proper practice, and causes for the recurrence of varicose veins is needed. Methods. We investigated a total number of 187 patients in a five year period with an estradiol-2/free testosterone (E2/fT) ratio relationship on recurrent varicose veins in men between the ages of 20-50. Fifity years was the maximum age due to the age dependent sex steroid hormone regression that occurs after this age, which may interefere with the assessment. Fifty three men with an elevated E2/fT ratio (group A), and 143 men with no endocrinologic problems (group B) were enrolled in the study and had surgery for varicose veins. After 5 years follow up (mean 3 years), Group A (N.=29) and group B (N.=43) had recurrent varicose veins by clinical and radiologic findings. Venous blood samples were driven from all patients of both groups in the morning to detect the levels of serum E2 and fT levels. Patient history of surgery for varicose veins, physical examination, color duplex ultrasound of both limbs, and classification of CEAP were performed in both groups. Results. The serum E2/fT ratio was significantly higher in Group A (5.21 +/- 0.56) compared to group B (2.54 +/- 0.27) in the recurrent varicose vein groups (p <= 0.05). Moreover, there was a high correlation between serum E2/fT ratio and the CEAP clinical classification in group A (5) compared to group B (2) (P <= 0.05). Also, recurrence rate was higher in group A (54%) compared to group B (32%)(P <= 0.05). Conclusion. Elevated serum E2/fT ratio is a precipitating factor for recurrent varicose veins in male patients.
dc.description.sponsorshipDicle University DUBAP
dc.description.sponsorshipWe are grateful to Dicle University DUBAP for their sponsorship about language editing of this manuscript.
dc.identifier.endpage581
dc.identifier.issn0392-9590
dc.identifier.issn1827-1839
dc.identifier.issue6
dc.identifier.pmid25791489
dc.identifier.scopus2-s2.0-84988528187
dc.identifier.scopusqualityQ3
dc.identifier.startpage576
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27072
dc.identifier.volume34
dc.identifier.wosWOS:000369559400011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofInternational Angiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectVaricose veins
dc.subjectVenous insufficiency
dc.subjectGonadal steroid hormones
dc.titleSerum estradiol/free testosterone ratio can be important predictor for varicose vein recurrence in men
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu