Relationship between genetic polymorphisms MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes and multiple sclerosis: a case-control study

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dc.authoridOcak, Ozgul/0000-0001-8276-0174
dc.contributor.authorCakina, Suat
dc.contributor.authorOcak, Ozgul
dc.contributor.authorOzkan, Adile
dc.contributor.authorYucel, Selma
dc.contributor.authorKaraman, Handan Isin Ozisik
dc.date.accessioned2025-01-27T20:38:36Z
dc.date.available2025-01-27T20:38:36Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractRecent studies have reported elevated plasma homocysteine and reduced folate and vitamin B levels in patients with multiple sclerosis (MS). In this study, we aimed to investigate the association between MS and the following four DNA polymorphisms: MTR A[2756]G, MTHFR C[677]T, MTHFR A[1298]C and MTRR A[66]G. The DNA polymorphisms were genotyped in 80 patients with confirmed MS and 80 healthy control age- and gender-matched subjects using PCR-RFLP approach. Our results show that the frequency of the T/T genotype homozygotes for the MTHFR C[677]T polymorphism was significantly higher in patients than in controls (p = 0.04, OR: 3.16, 95% CI: 1.23-8.17). In turn, the A/A genotype of the MTHFR A[1298]C polymorphism was more frequent in controls than in patients (41.3% vs. 32.5%, p = 0.04). There were no differences in distribution of genotypes for the MTR A[66]G and MTR A[2756]C polymorphisms between patients with MS and controls (p > 0.05). Our findings suggested that the MTHFR C[677]T and MTHFR A[1298] C gene polymorphisms might be associated with MS as genetic factors influencing the risk of the disease.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University [TSA-972]
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University. Project Number: TSA-972.
dc.identifier.doi10.5114/fn.2019.83829
dc.identifier.endpage40
dc.identifier.issn1641-4640
dc.identifier.issn1509-572X
dc.identifier.issue1
dc.identifier.pmid31038186
dc.identifier.scopus2-s2.0-85064159002
dc.identifier.scopusqualityQ3
dc.identifier.startpage36
dc.identifier.urihttps://doi.org/10.5114/fn.2019.83829
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23658
dc.identifier.volume57
dc.identifier.wosWOS:000462988400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofFolia Neuropathologica
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectDNA polymorphism
dc.subjectMTHFR gene
dc.subjectMTR gene
dc.subjectMTRR gene
dc.subjectmultiple sclerosis
dc.titleRelationship between genetic polymorphisms MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes and multiple sclerosis: a case-control study
dc.typeArticle

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