The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

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dc.contributor.authorGoret, Ceren Canbey
dc.contributor.authorGoret, Nuri Emrah
dc.contributor.authorKiraz, Asli
dc.contributor.authorOzkan, Omer Faruk
dc.contributor.authorKaraayvaz, Muammer
dc.date.accessioned2025-01-27T20:49:41Z
dc.date.available2025-01-27T20:49:41Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To investigate the effects of pycnogenol on peritoneal adhesions and additionally to investigate the immunohistochemical effects of free oxygen radicals and reactive lymph nodes detected in the adhesive tissue that was sampled surrounding the cecum on intra-abdominal adhesions. Methods: Twenty-seven Wistar Albino rats were divided into three groups. In group 1 (sham), laparotomy was performed and stitched up. In group 2 (control), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered 2 cc of saline. In group 3 (experimental), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered a sterile Pycnogenol derivative. The rats in all groups were re-laparotomized on postoperative day 7; samples were obtained from the peritoneal tissue surrounding the cecum, and the rats were sacrificed. Results: In group 3, there was a statistically significant difference in terms of inflammation, lymph node size, and free oxygen radicals; these parameters tended to increase. In terms of fibrosis evaluated using H&E and MT, there was no significant difference between groups 2 and 3. Conclusions: No positive outcomes indicating that pycnogenol reduces intra-abdominal adhesions were obtained. However, it caused severe inflammation in the tissue. Moreover, a significant increase in lymph node size was detected secondary to inflammation. Additionally, in immunohistochemical analyses conducted to detect oxidative stress, pycnogenol increased the production of free oxygen radicals in the tissue.
dc.identifier.doi10.1590/s0102-865020180020000005
dc.identifier.endpage143
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue2
dc.identifier.pmid29513812
dc.identifier.scopus2-s2.0-85042905208
dc.identifier.scopusqualityQ2
dc.identifier.startpage134
dc.identifier.urihttps://doi.org/10.1590/s0102-865020180020000005
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25276
dc.identifier.volume33
dc.identifier.wosWOS:000426974600005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPycnogenol
dc.subjectLymphadenopathy
dc.subjectFree Radicals
dc.subjectRats
dc.titleThe effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats
dc.typeArticle

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