The effects of serum leptin levels on thrombocyte aggregation in peritoneal dialysis patients

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dc.authoridBakirdogen, Serkan/0000-0002-3448-0490
dc.authoridGokcay Bek, Sibel/0000-0003-3325-5993
dc.contributor.authorBakirdogen, Serkan
dc.contributor.authorEren, Necmi
dc.contributor.authorBek, Sibel Gokcay
dc.contributor.authorMehtap, Ozgur
dc.contributor.authorCekmen, Mustafa Baki
dc.date.accessioned2025-01-27T20:38:38Z
dc.date.available2025-01-27T20:38:38Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Serum leptin levels of chronic kidney disease patients have been detected higher than normal population. The aim of this study was to investigate the effects of serum leptin levels on thrombocyte aggregation in peritoneal dialysis patients. Methods: Fourty three peritoneal dialysis patients were included in the study. Thrombocyte aggregation was calculated from the whole blood subsequently the effects of different concentrations of human recombinant leptin on thrombocyte aggregations were investigated. Four test cells were used for this process. While leptin was not added into the first test cell, increasing amounts of leptin was added into the second, third and fourth test cells to attain the concentrations of 25, 50 and 100 ng/ml respectively. Results: Thrombocyte aggregation was inhibited by recombinant leptin in peritoneal dialysis patients. Thrombocyte aggregation mean values were found statistically significantly higher in first test cell when compared to leptin groups in peritoneal dialysis patients. For leptin groups we could not find any statistically significant differences for thrombocyte aggregation mean values between any of the groups. Conclusion: Further studies with larger number of peritoneal dialysis patients are required to prove the action of leptin on thrombocyte aggregation.
dc.identifier.doi10.12669/pjms.326.11021
dc.identifier.endpage1467
dc.identifier.issn1682-024X
dc.identifier.issue6
dc.identifier.pmid28083046
dc.identifier.scopus2-s2.0-85007413344
dc.identifier.scopusqualityQ1
dc.identifier.startpage1464
dc.identifier.urihttps://doi.org/10.12669/pjms.326.11021
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23677
dc.identifier.volume32
dc.identifier.wosWOS:000390329600029
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherProfessional Medical Publications
dc.relation.ispartofPakistan Journal of Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPeritoneal Dialysis
dc.subjectThrombocyte Aggregation
dc.subjectHuman Recombinant Leptin
dc.titleThe effects of serum leptin levels on thrombocyte aggregation in peritoneal dialysis patients
dc.typeArticle

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