Is hyperbaric oxygen or ozone effective in experimental endocarditis?

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dc.authoridCicek, Omer Faruk/0000-0002-4675-3273
dc.contributor.authorOzkan, Muhammed Turgut Alper
dc.contributor.authorVural, Ahmet
dc.contributor.authorCicek, Omer Faruk
dc.contributor.authorYener, Ali Umit
dc.contributor.authorOzcan, Sedat
dc.contributor.authorToman, Huseyin
dc.contributor.authorUnver, Ahmet
dc.date.accessioned2025-01-27T21:00:00Z
dc.date.available2025-01-27T21:00:00Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Infective endocarditis, a disease with high mortality and morbidity, is most commonly caused by Staphylococcus aureus; mortality and morbidity further increase in the presence of methicillin-resistant strains of S. aureus. Linezolid is the first of the oxazolidinones, a new antibiotic group that has been approved for the treatment of infections caused by gram-positive cocci. Linezolid reduces the quantity of microorganisms in vegetation to some extent; in addition, the use of hyperbaric oxygen (HBO) and ozone (O-3) therapies is likely to improve targeted antibacterial effect. Materials and methods: Fifty-six adult male Wistar rats weighing 300-350 g were used. The subjects were divided into groups as follows: Group 1 (n = 8): control group that was not inoculated with microorganisms and was untreated; Group 2 (n = 8): control group that was inoculated with microorganisms but was untreated; Group 3 (n = 8): linezolid treatment group; Group 4 (n = 8): O-3 therapy group; Group 5 (n = 8): HBO therapy group; Group 6 (n = 8): linezolid + O-3 therapy group; Group 7 (n = 8): linezolid + HBO therapy group. Results: In terms of reducing the number of colonies in the aortic valve, linezolid + HBO therapy was found to be the most effective treatment. Then, respectively linezolid + O-3, linezolid, HBO, and O-3 were found to be effective. Conclusions: We found that linezolid significantly reduced the number of bacteria in the vegetation in the experimental endocarditis model, and HBO therapy increases the effectiveness of linezolid and makes this better than O-3. (C) 2016 Elsevier Inc. All rights reserved.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Commission [TSA-2013-168]
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart University Scientific Research Projects Commission (no: TSA-2013-168).
dc.identifier.doi10.1016/j.jss.2015.12.006
dc.identifier.endpage70
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue1
dc.identifier.pmid27083949
dc.identifier.scopus2-s2.0-84960919270
dc.identifier.scopusqualityQ1
dc.identifier.startpage66
dc.identifier.urihttps://doi.org/10.1016/j.jss.2015.12.006
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26907
dc.identifier.volume202
dc.identifier.wosWOS:000374969800009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofJournal of Surgical Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCardiovascular surgery
dc.subjectHyperbaric Oxygen
dc.subjectOzone
dc.subjectLinezolide
dc.subjectEndocarditis
dc.titleIs hyperbaric oxygen or ozone effective in experimental endocarditis?
dc.typeArticle

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