The protective effect of fish n-3 fatty acids on cerebral ischemia in rat prefrontal cortex

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dc.authoridMollaoglu, Hakan/0000-0002-6523-5607
dc.authoridSongur, Ahmet/0000-0002-6683-5495
dc.authoridOzen, Oguz Aslan/0000-0003-2521-0031
dc.contributor.authorOzen, Oguz Aslan
dc.contributor.authorCosar, Murat
dc.contributor.authorSahin, Onder
dc.contributor.authorFidan, Huseyin
dc.contributor.authorEser, Olcay
dc.contributor.authorMollaoglu, Hakan
dc.contributor.authorAlkoc, Ozan
dc.date.accessioned2025-01-27T21:01:27Z
dc.date.available2025-01-27T21:01:27Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study presents neuroprotective effects of fish n-3 EFA on the prefrontal cortex after cerebral ischemia and reperfusion. Eighteen rats divided into three groups. Group A rats were used as control. Cerebral ischemia and reperfusion was produced in rats either on a standard diet (Group B) or a standard diet plus fish n-3 EFA for 14 days (Group C). The malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD) and catalase (CAT) were measured and the number of apoptotic neurons was counted. The levels of MDA and activities of SOD increased in Group B rats as compared to Group A rats, and decreased in Group C rats as compared to Group B rats. The activities of CAT increased in Group C as compared to Group B rats. The number of apoptotic neurons in the prefrontal cortex was lower in Group C as compared to Group B rats.
dc.identifier.doi10.1007/s10072-008-0926-1
dc.identifier.endpage152
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue3
dc.identifier.pmid18612761
dc.identifier.scopus2-s2.0-48949116340
dc.identifier.scopusqualityQ1
dc.identifier.startpage147
dc.identifier.urihttps://doi.org/10.1007/s10072-008-0926-1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27044
dc.identifier.volume29
dc.identifier.wosWOS:000257491700003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer-Verlag Italia Srl
dc.relation.ispartofNeurological Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcerebral ischemia
dc.subjectfish n-3 fatty acids
dc.subjectprefrontal cortex
dc.subjectrat
dc.titleThe protective effect of fish n-3 fatty acids on cerebral ischemia in rat prefrontal cortex
dc.typeArticle

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