Orexin and adiponectin in high fat diet-induced insulin resistance

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dc.contributor.authorGulen, Meltem Ickin
dc.contributor.authorBagla, Aysel Guven
dc.contributor.authorYavuz, Ozlem
dc.contributor.authorHismiogullari, Adnan Adil
dc.date.accessioned2025-01-27T20:38:50Z
dc.date.available2025-01-27T20:38:50Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOrexin A (OXA) is a hypothalamic neuropeptide with both central and peripheral activities on insulin signaling and energy balance. Adiponectin is an adipocytokine which regulates metabolisms of lipid and glucose via its receptors AdipoR1 and AdipoR2. This study investigated immunohistochemical changes in expressions of OXA, its receptor OX1R in pancreas and AdipoR1 in skeletal muscle with a high fat diet (HFD)-induced insulin resistance (IR). Standard 45% fat and 60% fat diets were administered to Wistar rats for 3 and 8 w. OXA expression increased with both 3- and 8-w 45% fat diets. OX1R expression also increased with a 3-w 45% fat diet, but decreased with the 3-w 60% fat diet. OXA, OX1R, and AdipoR1 expressions decreased with a 8-w 60% fat diet. An early adaptation in context of OXA was observed in pancreas beta-cell to HFD-induced IR. OXA, OX1R, and AdipoR1 expressions decreased with either the higher amount or longer duration of HFD consumption.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [111S-302]
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey under grant number [111S-302];
dc.identifier.doi10.1080/01478885.2018.1520952
dc.identifier.endpage12
dc.identifier.issn0147-8885
dc.identifier.issn2046-0236
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85055471354
dc.identifier.scopusqualityQ2
dc.identifier.startpage3
dc.identifier.urihttps://doi.org/10.1080/01478885.2018.1520952
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23773
dc.identifier.volume42
dc.identifier.wosWOS:000462337800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Histotechnology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAdiponectin receptor 1
dc.subjecthigh fat diet
dc.subjectinsulin resistance
dc.subjectorexin A
dc.subjectorexin receptor 1
dc.subjectpancreas
dc.subjectrat
dc.subjectskeletal muscle
dc.titleOrexin and adiponectin in high fat diet-induced insulin resistance
dc.typeArticle

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