Crosslinked poly(Lactose) microgels and nanogels for biomedical applications

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dc.authoridCan, Mehmet / 0000-0002-5993-206X
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorCan, Mehmet
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:26:56Z
dc.date.available2025-01-27T20:26:56Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHypothesis: Lactose (LAC) is a primary carbohydrate and energy source of milk has received intensive attention due to its' unique functional and nutritional properties. Many biological beneficences of LAC make it an appealing molecule to seek for designing functional interfaces. Therefore, crosslinked poly(lactose) (p(LAC)) microgel from lactose disaccharides for potential biomedical applications was pursued as biocolloids for the first time. Experiment: p(LAC) microgels prepared by chemical crosslinking with DiVinyl Sulfone (DVS) were chemically modified with ethylenediamine (EDA) to obtain amine-modified p(LAC) (p(LAC)-EDA) microgels to induce new functionalities and properties. Blood compatibilities of bare p(LAC)-EDA microgels were tested through hemolysis and blood clotting tests. Rosmarinic acid (RA) used as a model drug was loaded into p(LAC) and p(LAC)-EDA microgels to demonstrate their applicability to be used in drug loading and release applications. Findings: A facile preparation of p(LAC) microgels with high yield, 90 +/- 5% and 0.5-50 mu m size range was accomplished via water-in-oil (w/o) microemulsion crosslinking method. Upon chemical modification, the isoelectric point (IEP) from pH 1.8 for p(LAC) microgels changed to pH 7.7 for p(LAC)-EDA microgels, and the blood compatibility studies revealed that both microgels can be considered as blood compatible up to 2 mg/mL concentration, and only slight decrease in blood clotting index (BCI) of p(LAC)-EDA microgels was observed. Rosmarinic Acid (RA) was demonstrated to be released up to 4 days in phosphate buffer saline (PBS) with a linear release profile for p(LAC)-EDA microgels. (C) 2019 Elsevier Inc. All rights reserved.
dc.description.sponsorshipScientific Research Commission of Canakkale Onsekiz Mart University (COMU BAP) [FBA-2018-2674]
dc.description.sponsorshipThe study was supported by the Scientific Research Commission of Canakkale Onsekiz Mart University (COMU BAP, FBA-2018-2674).
dc.identifier.doi10.1016/j.jcis.2019.06.078
dc.identifier.endpage812
dc.identifier.issn0021-9797
dc.identifier.issn1095-7103
dc.identifier.pmid31255942
dc.identifier.scopus2-s2.0-85067929364
dc.identifier.scopusqualityQ1
dc.identifier.startpage805
dc.identifier.urihttps://doi.org/10.1016/j.jcis.2019.06.078
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22510
dc.identifier.volume553
dc.identifier.wosWOS:000483454400084
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofJournal of Colloid and Interface Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectLactose microgel/nanogel
dc.subjectFunctional interface
dc.subjectDrug delivery
dc.subjectBiocolloid
dc.subjectSugar particles
dc.titleCrosslinked poly(Lactose) microgels and nanogels for biomedical applications
dc.typeArticle

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