4-phenyl butyric acid improves hepatic ischemia/reperfusion and affects gene expression of ABC transporter Abcc5 in rats

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dc.contributor.authorGuven, Bulent Baris
dc.contributor.authorTanoglu, Alpaslan
dc.contributor.authorOzcelik, Fatih
dc.contributor.authorTanoglu, Esra Guzel
dc.contributor.authorTerzi, Neslihan Kaya
dc.date.accessioned2025-01-27T20:29:00Z
dc.date.available2025-01-27T20:29:00Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim To assess the effects of 4-phenyl butyric acid (PBA) on oxidative stress, inflammation, liver histology, endoplasmic (ER) reticulum stress, and the expression levels of ATP -binding cassette transporter family members in a hepatic ischemia-reper fusion (IR) model.Methods Thirty-five rats were randomly divided into five groups: sham, IR, IR + 100 mg kg-1 PBA, IR + 200 mg kg-1 PBA, and IR + placebo. After sacrifice, we assessed serum biochemical variables, myeloperoxidase (MPO), malondialdehyde (MDA), total antioxidant status (TAS), and total oxidant status (TOS). The expression levels of Abcc (2 and 5), Abcg2, Abcf2, Ire1-alpha, and Perk genes were measured with a quantitative real-time polymerase chain reaction.Results Serum biochemical variables, MPO, MDA, TAS, and TOS levels of the PBA groups (especially in the low dose group) were lower than in the IR and placebo group (P < 0.05). Histological tissue damage in the IR group was more severe than in the PBA groups. Ire1-alpha and Perk expression levels were significantly lower in the PBA groups than the IR group (P < 0.001). Abcc (2 and 5) and Abcg2 expression levels were significantly lower in the IR group than in the sham and PBA groups (P < 0.001, P < 0.035, and P < 0.009, respectively).Conclusions The use of PBA significantly positively affected IR injury, which makes PBA a candidate treatment to reduce liver IR.
dc.identifier.doi10.3325/cmj.2023.64.391
dc.identifier.endpage403
dc.identifier.issn0353-9504
dc.identifier.issn1332-8166
dc.identifier.issue6
dc.identifier.pmid38168520
dc.identifier.scopus2-s2.0-85181633427
dc.identifier.scopusqualityQ2
dc.identifier.startpage391
dc.identifier.urihttps://doi.org/10.3325/cmj.2023.64.391
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22773
dc.identifier.volume64
dc.identifier.wosWOS:001146300600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedicinska Naklada
dc.relation.ispartofCroatian Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectEndoplasmic-Reticulum-Stress
dc.subjectIschemia-Reperfusion Injury
dc.subjectCancer Resistance Protein
dc.subjectLiver Ischemia
dc.subjectOxidative Stress
dc.subjectN-Acetylcysteine
dc.subjectApoptosis
dc.subjectDonors
dc.subjectCells
dc.subjectMrp2
dc.title4-phenyl butyric acid improves hepatic ischemia/reperfusion and affects gene expression of ABC transporter Abcc5 in rats
dc.typeArticle

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