Evaluation of the Antidepressant Effect of Propolis in Chronic Unpredictable Mild Stress-induced Depression Model in Rats

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dc.authoridCANBOLAT, FADIME/0000-0001-6759-7735
dc.authoridYucelli, Sena/0000-0003-0290-8330
dc.contributor.authorTaskiran, Ali
dc.contributor.authorCanbolat, Fadime
dc.contributor.authorYucelli, Sena Nur
dc.contributor.authorCevreli, Burcu
dc.date.accessioned2025-01-27T20:57:51Z
dc.date.available2025-01-27T20:57:51Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: In this study, the antidepressant effect of propolis was investigated in a model of chronic unpredictable depression in rats. Materials and Methods: Wistar-Albino male rats were used in the study and were divided into four groups as propolis, stress, stress+propolis, and control groups. Eight animals were assigned to each group. The experimental protocol was applied to the stress groups for 60 days, and the animals were exposed to different stressors. Propolis extract (100 mg/kg) was administered orally to propolis and stress+propolis groups throughout the experimental protocol. As a result of depression modeling, the Forced Swimming Test, Sucrose Preference Test, and Elevated Plus Maze Test were applied for behavioral evaluation. 24-hour urine samples were collected for quantification analysis of serotonin (5-HT) and its metabolite 5-hydroxy indole acetic acid (5-HIAA) in urine by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. The animals were sacrificed as a result of the experiment process. The results obtained from the study were analyzed using the Statistical Package for the Social Sciences. Results: It was seen that there was a statistical difference for behavioral tests between the groups (p<0.05). The administration of propolis to rats under stress has been shown to alter sugar consumption in rats (p<0.05). For Forced Swimming Test, there was a statistical difference between the stress group and the other groups. For 5-HT and 5-HIAA levels, there was no significant difference between the groups (p>0.05). Conclusion: The findings have shown that propolis extract may help to prevent depression, thanks to its antidepressant-like effects.
dc.description.sponsorshipUskuedar University Institute of Science [688552]
dc.description.sponsorshipThe authors declared that this study received no financial support . This article was produced in 2021 from the master's thesis no. 688552 in Uskuedar University Institute of Science.
dc.identifier.doi10.4274/nkmj.galenos.2023.48303
dc.identifier.endpage104
dc.identifier.issn2587-0262
dc.identifier.issue2
dc.identifier.startpage94
dc.identifier.trdizinid1184523
dc.identifier.urihttps://doi.org/10.4274/nkmj.galenos.2023.48303
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1184523
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26524
dc.identifier.volume11
dc.identifier.wosWOS:001186687300009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofNamik Kemal Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSerotonin
dc.subjectdepression
dc.subjectpropolis
dc.subjectchronic unpredictable stress model
dc.titleEvaluation of the Antidepressant Effect of Propolis in Chronic Unpredictable Mild Stress-induced Depression Model in Rats
dc.typeArticle

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