Associations of Annual Ambient Fine Particulate Matter Mass and Components with Mitochondrial DNA Abundance

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dc.authoridCAYIR, AKIN/0000-0002-2014-6635
dc.authoridColicino, Elena/0000-0002-1875-8448
dc.authoridSanchez-Guerra, Marco/0000-0002-8354-1157
dc.contributor.authorPeng, Cheng
dc.contributor.authorCayir, Akin
dc.contributor.authorSanchez-Guerra, Marco
dc.contributor.authorDi, Qian
dc.contributor.authorWilson, Ander
dc.contributor.authorZhong, Jia
dc.contributor.authorKosheleva, Anna
dc.date.accessioned2025-01-27T20:12:07Z
dc.date.available2025-01-27T20:12:07Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Fine particulate matter (PM2.5) represents a mixture of components with potentially different toxicities. However, little is known about the relative effects of PM2.5 mass and PM2.5 components on mitochondrial DNA (mtDNA) abundance, which may lie on the pathway of PM2.5-associated disease. Methods: We studied 646 elderly male participants in the Normative Aging Study from Greater Boston to investigate associations of long-term exposure to PM2.5 mass and PM2.5 components with mtDNA abundance. We estimated concentrations of pollutants for the 365-day preceding examination at each participant's address using spatial- and temporal-resolved chemical transport models. We measured blood mtDNA abundance using RT-PCR. We applied a shrinkage and selection method (adaptive LASSO) to identify components most predictive of mtDNA abundance, and fit multipollutant linear mixed-effects models with subject-specific intercept to estimate the relative effects of individual PM component. Results: MtDNA abundance was negatively associated with PM2.5 mass in the previous year and-after adjusting for PM2.5 mass-several PM2.5 components, including organic carbon, sulfate (marginally), and nitrate. In multipollutant models including as independent variables PM2.5 mass and PM2.5 components selected by LASSO, nitrate was associated with mtDNA abundance. An SD increase in annual PM2.5-associated nitrate was associated with a 0.12 SD (95% confidence intervals [CI] = -0.18, -0.07) decrease in mtDNA abundance. Analyses restricted to PM2.5 annual concentration below the current 1-year U.S. Environmental Protection Agency standard produced similar results. Conclusions: Long-term exposures to PM2.5-associated nitrate were related to decreased mtDNA abundance independent of PM2.5 mass. Mass alone may not fully capture the potential of PM2.5 to oxidize the mitochondrial genome. See video abstract at, http://links.lww.com/EDE/B274.
dc.description.sponsorshipNIEHS NIH HHS [P30 ES009089, R21 ES021895, R01 ES021733, P30 ES000002, R01 ES021357, R01 ES015172] Funding Source: Medline
dc.identifier.doi10.1097/EDE.0000000000000717
dc.identifier.endpage770
dc.identifier.issn1044-3983
dc.identifier.issn1531-5487
dc.identifier.issue6
dc.identifier.pmid28953603
dc.identifier.scopus2-s2.0-85045685387
dc.identifier.scopusqualityQ1
dc.identifier.startpage763
dc.identifier.urihttps://doi.org/10.1097/EDE.0000000000000717
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20853
dc.identifier.volume28
dc.identifier.wosWOS:000411901200011
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofEpidemiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAir-Pollution
dc.subjectUnited-States
dc.subjectCopy Number
dc.subjectBlood-Pressure
dc.subjectMortality
dc.subjectPm2.5
dc.subjectConstituents
dc.subjectExposure
dc.subjectHealth
dc.subjectDamage
dc.titleAssociations of Annual Ambient Fine Particulate Matter Mass and Components with Mitochondrial DNA Abundance
dc.typeArticle

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