An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy

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dc.authoridKuzucu, Mehmet/0000-0002-7786-7687
dc.authoridAdali, Yasemen/0000-0002-8004-7364
dc.contributor.authorOzturk, Omur
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorUstebay, Sefer
dc.contributor.authorKuzucu, Mehmet
dc.contributor.authorAdali, Yasemen
dc.date.accessioned2025-01-27T21:00:12Z
dc.date.available2025-01-27T21:00:12Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To compare the preventive effects of N-acetyl cysteine (NAC), ozone preconditioning and ozone treatment against contrast-induced nephropathy (CIN) in an experimental rat model. Methods: Thirty adult male Wistar rats were randomly distributed into five groups (n=6 for each group). Group I served as control and Group II had only contrast agent, while Group III received NAC and Group IV received Intraperitoneal ozone 6 hours before and 6 hours after Introduction of contrast agent. Ozone treatment was applied for 5 days after the contrast agent was Introduced in Group V. After induction of CIN, groups were compared in terms of serum levels of urea, creatinine, neutrophil gelatinase associated lipocalin, protein carbonyl, total antioxidant capacity (TAC) as well as degree of renal Injury at histopathologic level. Results: Groups II-V displayed more obvious histopathological alterations such as hemorrhage and renal tubular Injury compared with Group I. TAC(p=0.043) and creatinine (p=0.046) levels Increased significantly in Group II after the intervention. In Group III, protein carbonyl level diminished remarkably (p=0.046), while creatinine level was increased (p=0.046) following the intervention. TAC level was higher in Group IV (p=0.028) and Group V (p=0.026) following the procedure. Conclusion: The N-acetyl cysteine and ozone treatment may alleviate the biochemical and histopathological deleterious effects of contrast-induced nephropathy via enhancement of total antioxidant capacity and decreasing oxidative stress.
dc.identifier.doi10.1590/s0102-865020180060000005
dc.identifier.endpage517
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue6
dc.identifier.pmid30020312
dc.identifier.scopus2-s2.0-85050480638
dc.identifier.scopusqualityQ2
dc.identifier.startpage508
dc.identifier.urihttps://doi.org/10.1590/s0102-865020180060000005
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26962
dc.identifier.volume33
dc.identifier.wosWOS:000438900400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAcetylcysteine
dc.subjectOzone
dc.subjectPrevention
dc.subjectRats
dc.titleAn experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy
dc.typeArticle

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