Interpenetrating polymeric network hydrogels for potential gastrointestinal drug release

Basit Öğe Kaydı
dc.authoridSaraydin, Dursun/0000-0001-7191-510X
dc.contributor.authorEkici, Sema
dc.contributor.authorSaraydin, Dursun
dc.date.accessioned2025-01-27T20:52:05Z
dc.date.available2025-01-27T20:52:05Z
dc.date.issued2007
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNew interpenetrating polymeric network (IPN) hydrogels based on chitosan (C), poly(N-vinyl pyrrolidone) (PVP) and poly(acrylic acid) (PAAc), crosslinked with glutaraldchyde (G) and N,N'-methylenebisacrylamide (MBA), were prepared and investigated for potential gastrointestinal drug delivery vehicles utilizing a model drug, amoxicillin. IPN hydrogels were synthesized by simultaneous polymerization/crosslinking of acrylic acid monomer in the presence of another polymer (C) and crosslinker (G, MBA). Three different concentrations of glutaraldehyde were used (0.5, 1.0 and 2.0 w/w) to control the overall porosity of the hydrogels, named C-P-AAc/0.5, C-P-AAc/1.0 and C-P-AAc/2.0, respectively. Spectroscopic and thermal analyses such as Fourier transform infrared spectroscopy, thermogravimetric analysis and thermornechanical analysis were performed for IPN characterization. Equilibrium swelling studies were conducted for pH and temperature response behavior. Swelling studies were also carried out in simulated gastric fluid of pH = 1.1 and simulated intestinal fluid of pH = 7.4 to investigate possible site-specific drug delivery. It was found that the release behavior of the drug from these IPN hydrogels was dependent on the pH of the medium and the proportion of crosslinker in the IPN. It was observed that amoxicillin release at pH = 7.4 was higher than at pH = 1.1. The analysis of the drug release showed that amoxicillin was released from these hydrogels through a non-Fickian diffusion mechanism. (c) 2007 Society of Chemical Industry.
dc.identifier.doi10.1002/pi.2271
dc.identifier.endpage1377
dc.identifier.issn0959-8103
dc.identifier.issue11
dc.identifier.scopus2-s2.0-35348852456
dc.identifier.scopusqualityQ1
dc.identifier.startpage1371
dc.identifier.urihttps://doi.org/10.1002/pi.2271
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25652
dc.identifier.volume56
dc.identifier.wosWOS:000250254800008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJohn Wiley & Sons Ltd
dc.relation.ispartofPolymer International
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectIPN hydrogels
dc.subjectdrug release
dc.subjectpH-sensitive release
dc.subjectamoxicillin
dc.subjectpoly(acrylic acid)
dc.titleInterpenetrating polymeric network hydrogels for potential gastrointestinal drug release
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu