The potential of lactoferrin as antiviral and immune-modulating agent in viral infectious diseases

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dc.contributor.authorEker, Furkan
dc.contributor.authorDuman, Hatice
dc.contributor.authorErturk, Melih
dc.contributor.authorKarav, Sercan
dc.date.accessioned2025-01-27T20:24:39Z
dc.date.available2025-01-27T20:24:39Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractEmerging infectious diseases are caused by unpredictable viruses with the dangerous potential to trigger global pandemics. These viruses typically initiate infection by utilizing the anionic structures of host cell surface receptors to gain entry. Lactoferrin (Lf) is a multifunctional glycoprotein with multiple properties such as antiviral, anti-inflammatory and antioxidant activities. Due to its cationic structure, Lf naturally interacts with certain host cell receptors, such as heparan sulfate proteoglycans, as well as viral particles and other receptors that are targeted by viruses. Therefore, Lf may interfere with virus-host cell interactions by acting as a receptor competitor for viruses. Herein we summarize studies in which this competition was investigated with SARS-CoV-2, Zika, Dengue, Hepatitis and Influenza viruses in vitro. These studies have demonstrated not only Lf's competitive properties, but also its potential intracellular impact on host cells, such as enhancing cell survival and reducing infection efficiency by inhibiting certain viral enzymes. In addition, the immunomodulatory effect of Lf is highlighted, as it can influence the activity of specific immune cells and regulate cytokine release, thereby enhancing the host's response to viral infections. Collectively, these properties promote the potential of Lf as a promising candidate for research in viral infectious diseases.
dc.identifier.doi10.3389/fimmu.2024.1402135
dc.identifier.issn1664-3224
dc.identifier.pmid39620218
dc.identifier.scopus2-s2.0-85210599714
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3389/fimmu.2024.1402135
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22308
dc.identifier.volume15
dc.identifier.wosWOS:001365976500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Immunology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectlactoferrin
dc.subjectheparan sulfate proteoglycans
dc.subjectviral interference
dc.subjectreceptor competition
dc.subjectimmune modulating
dc.subjectviral infectious diseases
dc.titleThe potential of lactoferrin as antiviral and immune-modulating agent in viral infectious diseases
dc.typeReview Article

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