CENTRAL NERVOUS SYSTEM COMPLICATIONS OF DIABETES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: A HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL EXAMINATION

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dc.contributor.authorGuven, Aysel
dc.contributor.authorYavuz, Ozlem
dc.contributor.authorCam, Meryem
dc.contributor.authorComunoglu, Cem
dc.contributor.authorServinc, Ozdemir
dc.date.accessioned2025-01-27T20:47:25Z
dc.date.available2025-01-27T20:47:25Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractDiabetes mellitus is a common, potentially serious metabolic disorder. Over the long term, diabetes leads to serious consequences in a number of tissues, especially those that are insulin insensitive (retina, neurons, kidneys). It also causes a variety of functional and structural disorders in the central and peripheral nervous systems. We investigated whether neurodegenerative changes were observable in the hippocampus, cortex, and cerebellum after 4 weeks of streptozotocin (STZ)-induced diabetes in rats and the effect(s) of melatonin. Male Wistar rats (n = 32) were divided into four groups (n = 8 each): untreated controls, melatonin-treated controls, untreated diabetics, and melatonin-treated diabetics. Experimental diabetes was induced by a single dose of STZ (60 mg/kg, intraperitoneal (ip)). For 3 days before the administration of STZ, melatonin (200 mu g/kg/day, ip) was injected and continued for 4 weeks. Sections of hippocampus, cortex, and cerebellum were stained with hematoxylin and eosin and examined using light microscopy. In addition, brain tissues were examined immunohistochemically for the expression of glial and neuronal markers, including glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), and heat shock protein-70 (HSP-70). No neurodegenerative changes were observed in the hippocampus, cortex, or cerebellum of the untreated diabetic group after 4 weeks compared with the other groups. We did not observe any change in GFAP, NSE, or HSP-70 immunostaining in the brain tissues of STZ-induced diabetic rats. In summary, after 4 weeks of STZ-induced diabetes in rats, no degenerative or immunohistochemical changes were detected in the hippocampus, cortex, or cerebellum.
dc.identifier.doi10.1080/00207450902841723
dc.identifier.endpage1169
dc.identifier.issn0020-7454
dc.identifier.issue8
dc.identifier.pmid19922346
dc.identifier.scopus2-s2.0-70350515727
dc.identifier.scopusqualityQ2
dc.identifier.startpage1155
dc.identifier.urihttps://doi.org/10.1080/00207450902841723
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24897
dc.identifier.volume119
dc.identifier.wosWOS:000268663600008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Neuroscience
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectdiabetes
dc.subjectglial fibrillary acidic protein
dc.subjectheat shock protein-70
dc.subjectmelatonin
dc.subjectneuron-specific enolase
dc.titleCENTRAL NERVOUS SYSTEM COMPLICATIONS OF DIABETES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: A HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL EXAMINATION
dc.typeArticle

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