Parathyroid Hormone and Heart Failure: Novel Biomarker Strategy

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dc.contributor.authorAltay, Hakan
dc.contributor.authorColkesen, Yucel
dc.date.accessioned2025-01-27T20:52:36Z
dc.date.available2025-01-27T20:52:36Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHeart failure (HF) is a clinical syndrome featuring cardiac pump failure along with signs and symptoms arising from salt and water retention mediated by activated renin-angiotensin-aldosterone system (RAAS). In addition to this cardiorenal perspective, HF is accompanied by a systemic illness, especially in advanced stages characterized by oxidative stress in various tissues, causing damage to soft tissue and bone. Secondary hyperparathyroidism (SHPT) which is also considered to contribute this systemic illness is therefore prominent in advanced HF. SHPT in HF occurs as a result of RAAS activation, prominent hyperaldosteronism, loop diuretic usage and decreased calcitriol level, all of which results in calcium excretion. We review the evidence that high parathyroid hormone (PTH) is associated with advanced HF, as well as evidence that it's associated with HF with preserved ejection fraction (HFPEF).
dc.identifier.doi10.2174/1871530311313010012
dc.identifier.endpage104
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.issue1
dc.identifier.pmid23369142
dc.identifier.scopus2-s2.0-84875837759
dc.identifier.scopusqualityQ2
dc.identifier.startpage100
dc.identifier.urihttps://doi.org/10.2174/1871530311313010012
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25804
dc.identifier.volume13
dc.identifier.wosWOS:000316443500012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targets
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBiomarker
dc.subjectheart failure
dc.subjectparathyroid hormone
dc.titleParathyroid Hormone and Heart Failure: Novel Biomarker Strategy
dc.typeArticle

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