The effects of human amniotic membrane on silicone related capsule formation in rats

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dc.authoridAYDIN, Mehmet Serif/0000-0002-6393-1465
dc.authoriduysal, omer/0000-0002-8833-697X
dc.contributor.authorAkyurek, Mustafa
dc.contributor.authorOrhan, Erkan
dc.contributor.authorAydin, Mehmet Serif
dc.contributor.authorUysal, Omer
dc.contributor.authorKarsidag, Semra
dc.date.accessioned2025-01-27T20:14:11Z
dc.date.available2025-01-27T20:14:11Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSilicone breast implants are commonly used materials in plastic surgery for breast augmentation and reconstruction and the most severe complication of silicone implants are capsule contraction which occurs in 40% of patients. The aim of our study is to evaluate how the amniotic membrane alters the capsule formation effects of silicone 24 wistar rats were used in the study. We placed a bare silicone block into the left side (Subgroup A) and single layer amniotic membrane coated silicone block into the right side (Subgroup B) of the rats back. The rats were then separated into three groups and in group 1 rats were euthanized after 3 weeks, in group 2 after 12 weeks and in group 3 after 24 weeks. Then capsule thickness, fibroblast and lymphocyte cell counts were evaluated for each sample. In Group 2 and group 3, the capsule thickness in Subgroup B was detected to be statistically significantly lower than that in Subgroup A. In Group 1, 2, and 3, the lymphocyte count in the capsule tissue taken from Subgroup B was lower than Subgroup A but the difference was not statistically significant. In Group 2 and 3, the fibrocyte count detected in the capsule tissue in Subgroup B was found to be statistically significantly lower than Subgroup A. the amniotic membrane was demonstrated to reduce capsule thickness by the antifibrinolytic effect in our study.
dc.identifier.doi10.1080/2000656X.2020.1766476
dc.identifier.endpage289
dc.identifier.issn2000-656X
dc.identifier.issn2000-6764
dc.identifier.issue5
dc.identifier.pmid32427012
dc.identifier.scopus2-s2.0-85085285557
dc.identifier.scopusqualityQ2
dc.identifier.startpage284
dc.identifier.urihttps://doi.org/10.1080/2000656X.2020.1766476
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20979
dc.identifier.volume54
dc.identifier.wosWOS:000536382600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Plastic Surgery and Hand Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAmniotic membran
dc.subjectcapsule formation
dc.subjectsilicone implant
dc.titleThe effects of human amniotic membrane on silicone related capsule formation in rats
dc.typeArticle

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