Synthesis and characterization of nitrogen-doped carbon dots as fluorescent nanoprobes with antimicrobial properties and skin permeability

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dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorDemirci, Şahin
dc.contributor.authorMcNally, Alexandra B.
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorLawson, Louise B.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:54:05Z
dc.date.available2025-01-27T20:54:05Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNitrogen doped carbon dots (N-doped C-dots) were prepared using polyethyleneimine (PEI) and citric acid (CA) as precursors via the hydrothermal method. Various weight ratios of PEI and CA, 1:0.5, 1:1, and 1:2, were used in the synthesis of N-doped C-dots. The N-doping of prepared C-dots was confirmed with an FT-IR peak that was observed at 1652 cm(-1) assigned to N-H bending. The hydrodynamic diameters of prepared N-doped C-dots were 70.2 +/- 6.9, 32.2 +/- 4.7, and 11.5 +/- 3.1 nm by DLS measurements, and surface charges values were 1.32 +/- 0.8, 0.14 +/- 0.2, and -1.57 +/- 0.7 mV, for 1:0.5, 1:1, and 1:2 wt ratio based on PEI of CA, respectively. A high quantum yield 53 +/- 4.8% according to quinine sulfate standard was determined for 1:1 C-dot prepared from 1:1 wt ratio of PEI:CA. The C-dots were found to inhibit growth of both Gram-negative and Gram-positive bacteria with no noted toxicity to mammalian cells in vitro. Skin permeation studies indicate that the particles permeate into and through the dermis within hours, indicating their potential use for topical administration.
dc.description.sponsorshipTulane University School of Medicine
dc.description.sponsorshipFunding for this work from Tulane University School of Medicine is gratefully acknowledged. The authors would like to thank Claire Pierce and Katherine Hebert for assistance with experimental work. The authors also would like to thank Ms. Yildiz Yildirim for the great contribution for XRD studies.
dc.identifier.doi10.1016/j.jddst.2020.101889
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85087708509
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2020.101889
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25969
dc.identifier.volume59
dc.identifier.wosWOS:000572446100007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCarbon dots
dc.subjectAntimicrobial
dc.subjectSkin permeability
dc.subjectBiocompatible particles
dc.titleSynthesis and characterization of nitrogen-doped carbon dots as fluorescent nanoprobes with antimicrobial properties and skin permeability
dc.typeArticle

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