Structural characterization and antimicrobial activity of 1,3-bis(2-benzimidazyl)-2-thiapropane ligand and its Pd(II) and Zn(II) halide complexes

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dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.contributor.authorAgh-Atabay, NM
dc.contributor.authorDulger, B
dc.contributor.authorGucin, F
dc.date.accessioned2025-01-27T20:44:08Z
dc.date.available2025-01-27T20:44:08Z
dc.date.issued2005
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstract1,3-Bis(2-benzimidazyl)-2-thiapropane(L) forms 5-coordinate square pyramidal and 4-coordinate tetrahedral, monometallic complexes with PdCl2 and ZnX2 (X = Cl, Br, I) respectively. In the palladium complex, the ligand acts as a chelating tridentate, through two of the nitrogen atoms in the imidazole ring and the sulfur atom of the bridging group together with two chloride ions forming a rare five coordinate complex. In the zinc halide complexes, the ligand acts as chelating bidentate, via two of the nitrogen atoms combined with two halide ions giving common tetrahedral complexes. The ligand and its complexes are characterized by analytical data and spectroscopic methods such as FT-aman, FT-IR (mid-IR, far-IR), H-1 and C-13 NMR. Their antimicrobial activities are evaluated by the minimal inhibitory concentration (MIC) against 10 bacteria, each with multiple, fresh clinical isolates (10-15), and the results are compared with those of ampicillin, ciprofloxacin, cefazolin, ofloxacin, and piperacillin antibacterial agents. The compound's antifungal activities are reported on Candida albicans, Candida utilis, and Cryptococcus neoformans yeasts, each with multiple isolates (10), and the results are referenced with amphotericin-B, fluconazole and flucytosine antifungal agents. In most cases, the compounds show broad-spectrum (Gram(+) and Gram(-)) activities that are either, more active, or equipotent to, the antibiotic and antifungal agents in the comparison tests. (c) 2005 Elsevier SAS. All rights reserved.
dc.identifier.doi10.1016/j.ejmech.2005.05.006
dc.identifier.endpage1102
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue11
dc.identifier.pmid15992966
dc.identifier.scopus2-s2.0-26844464414
dc.identifier.scopusqualityQ1
dc.identifier.startpage1096
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2005.05.006
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24485
dc.identifier.volume40
dc.identifier.wosWOS:000233184600004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectamphotericin-B
dc.subjectantifungal
dc.subjectantimicrobial
dc.subjectchelating
dc.subjectequipotent
dc.subjectfluconazole
dc.subjectmonometallic
dc.subjectpiperacillin
dc.subjectpyramidal
dc.subjecttridentate
dc.titleStructural characterization and antimicrobial activity of 1,3-bis(2-benzimidazyl)-2-thiapropane ligand and its Pd(II) and Zn(II) halide complexes
dc.typeArticle

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