Combined Germline Variations of Thrombophilic Genes Promote Genesis of Lung Cancer

Basit Öğe Kaydı
dc.contributor.authorOzen, Filiz
dc.contributor.authorPolat, Fikriye
dc.contributor.authorArslan, Sulhattin
dc.contributor.authorOzdemir, Ozturk
dc.date.accessioned2025-01-27T20:45:31Z
dc.date.available2025-01-27T20:45:31Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: A large variety of familiar and non-familiar lung carcinomas (LC) are caused by long term exposure to chemical carcinogens that are present in tobacco smoke. We aimed to investigate the prevalence of 5 thrombophilic germ-line mutations in patients with lung carcinomas. Materials and Methods: A total of 52 LC patients and 212 healthy controls from same population were analyzed for FV Leiden, factor V H1299R (R2), PAI-1, MTHFR C677T, MTHFR A1298C, ACE I/D, and Apo E genes and compared. Results: Overall, heterozygous and/or homozygous point mutations in FV Leiden Apo E2, PAI-1 and MTHFR C677T genes were associated with LC in the current cohort. There was no meaningful association between LC and ACE I/D gene markers. Conclusions: The current results showed that LC is related to combined thrombophilic gene mutations and individuals with homozygosity of 4G in PAI-1 and MTHFR C677T genes and heterozygosity of FV Leiden, Apo E4 genes have a germ-line risk for LC tumorigenesis.
dc.identifier.doi10.7314/APJCP.2013.14.9.5449
dc.identifier.endpage5454
dc.identifier.issn1513-7368
dc.identifier.issue9
dc.identifier.pmid24175756
dc.identifier.scopus2-s2.0-84887605283
dc.identifier.scopusqualityQ3
dc.identifier.startpage5449
dc.identifier.urihttps://doi.org/10.7314/APJCP.2013.14.9.5449
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24611
dc.identifier.volume14
dc.identifier.wosWOS:000328273000085
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAsian Pacific Organization Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectA case control study
dc.subjectcombined thrombophilic genes
dc.subjectlung cancer
dc.subjectgerm-line variations
dc.titleCombined Germline Variations of Thrombophilic Genes Promote Genesis of Lung Cancer
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu