Evaluation of circulating cell free DNA in plasma as a biomarker of different thyroid diseases

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dc.authoridCaglar Cil, ozge/0000-0001-8737-2891
dc.contributor.authorCaglar, Ozge
dc.contributor.authorCilgin, Begum
dc.contributor.authorEroglu, Mustafa
dc.contributor.authorCayir, Akin
dc.date.accessioned2025-01-27T20:41:14Z
dc.date.available2025-01-27T20:41:14Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Many studies have been done on proteomics, genomics, epigenetic, immuno-genetics in many body fluids. Among these, circulating cell-free DNA (ccfDNA) entered the literature in 1948, but it has not been studied for many years due to technological deficiencies. Following recent advances, geno-metastasis has been mentioned and new research is needed in this area. ccfDNA is known to be an important biomolecule in this regard. Objective: The presence of cell-free DNA in the circulatory system may offer a tremendous opportunity to provide novel biomarkers for thyroid diseases. This experimental study was conducted to determine the amount of ccfDNA in different thyroid diseases, then to evaluate whether the ccfDNA concentration varied between the disease groups and control group. Methods: In total, we included 121 individuals in the present study. We collected blood samples and then determined the ccfDNA concentration in plasma of collected blood samples from three groups: thyroiditis (n=33), benign (n =37), and malignant (n =30) and from a control group (n=21). Results: The median values of the ccfDNA groups were found as 1610, 1665, 1685 and 576 ng/mL for the thyroiditis, benign, malign, and control groups, respectively. Findings showed that the ccfDNA of the three groups was significantly higher than the control (p <0.0001). Each group was compared in terms of ccfDNA and the p-values of benign-thyroiditis, benign-malign, and thyroiditis-malign were 0.09, 0.65, and 0.29, respectively. Conclusions: The clear differences between thyroid diseases and controls suggest that ccfDNA is worthy of attention as a biomarker for further evaluation of different thyroid diseases. Likewise, it might indicate a clear tendency that ccfDNA can also be used to distinguish different thyroid diseases. (C) 2019 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.
dc.description.sponsorshipCanakkale Onsekiz Mart University The Scientific Research Coordination Unit (BAP) [TYL-2017-1114]
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University The Scientific Research Coordination Unit ((BAP), Project number: TYL-2017-1114).
dc.identifier.doi10.1016/j.bjorl.2018.12.008
dc.identifier.endpage326
dc.identifier.issn1808-8694
dc.identifier.issn1808-8686
dc.identifier.issue3
dc.identifier.pmid30826312
dc.identifier.scopus2-s2.0-85062094404
dc.identifier.scopusqualityQ2
dc.identifier.startpage321
dc.identifier.urihttps://doi.org/10.1016/j.bjorl.2018.12.008
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24076
dc.identifier.volume86
dc.identifier.wosWOS:000539723500009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectThyroid diseases
dc.subjectCell free DNA
dc.subjectPlasma
dc.subjectBiomarker
dc.titleEvaluation of circulating cell free DNA in plasma as a biomarker of different thyroid diseases
dc.title.alternativeAvaliação do DNA circulante livre de células no plasma como um biomarcador de diferentes doenças da tireoide
dc.typeArticle

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