Development and application of a sensitive, disposable and low-cost electrochemical sensing platform for an antimalarial drug: amodiaquine based on poly(calcein)-modified pencil graphite electrode

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dc.authoridKarakaya, Serkan/0000-0002-6401-3295
dc.contributor.authorKarakaya, Serkan
dc.contributor.authorKartal, Burcu
dc.contributor.authorDilgin, Yusuf
dc.date.accessioned2025-01-27T20:57:48Z
dc.date.available2025-01-27T20:57:48Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, an electrochemical sensor towards the determination of an antimalarial drug, amodiaquine (Adqn), was performed. The proposed sensor was fabricated by electro-polymerisation of calcein (CCN) onto pencil graphite electrode (PGE). The electrochemical behaviour of 0.40 mM Adqn at both poly(calcein)-modified pencil graphite electrode (poly(CCN)/PGE) and bare PGE was evaluated in pH 3.0 Britton-Robinson buffer solution by cyclic voltammetry (CV) method. The voltammograms indicated that poly(CCN)/PGE presents a remarkable response towards oxidation and reduction of Adqn compared with PGE. The characterisation studies at poly(CCN)/PGE were performed by recording the electrochemical impedance curves, scanning electron microscopy images and energy-dispersive X-ray spectra. To determine the analytical performance of the poly(CCN)/PGE, the parameters such as linear range, limit of detection and sensitivity were determined based on the oxidation of Adqn by differential pulse voltammetry (DPV) method and were calculated to be 0.50-25 mu M, 0.16 mu M and 20.566 mu A mu M-1, respectively. The recovery studies at poly(CCN)/PGE were carried out with various matrixes (tap water, artificial blood and maternal milk) by DPV-spike methods, and the high recovery values (99.2-100.6%) confirmed that poly(CCN)/PGE can be used towards sensitive and accurate determination of Adqn in different sample matrixes containing Adqn.
dc.description.sponsorshipScientific Research Coordination Unit of Canakkale Onsekiz Mart University [FBA-2019-3046]
dc.description.sponsorshipThis work was supported by the Scientific Research Coordination Unit of Canakkale Onsekiz Mart University, [Project number: FBA-2019-3046].
dc.identifier.doi10.1080/03067319.2020.1791332
dc.identifier.endpage5149
dc.identifier.issn0306-7319
dc.identifier.issn1029-0397
dc.identifier.issue17
dc.identifier.scopus2-s2.0-85087588795
dc.identifier.scopusqualityQ1
dc.identifier.startpage5136
dc.identifier.urihttps://doi.org/10.1080/03067319.2020.1791332
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26501
dc.identifier.volume102
dc.identifier.wosWOS:000547449300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Environmental Analytical Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAmodiaquine
dc.subjectantimalarial drug
dc.subjectcalcein
dc.subjectpencil graphite electrode
dc.subjectdifferential pulse voltammetry
dc.subjectelectrochemical sensor
dc.titleDevelopment and application of a sensitive, disposable and low-cost electrochemical sensing platform for an antimalarial drug: amodiaquine based on poly(calcein)-modified pencil graphite electrode
dc.typeArticle

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