Speciation of antimony in anti-leishmanial drug using two different chemical receptors and adsorptive anodic stripping voltammetry on glassy carbon electrode

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dc.authorid0000-0002-2980-6871 View this author’s ORCID profileen_US
dc.authorscopusid6507953466en_US
dc.authorwosidW-4565-2017en_US
dc.contributor.authorVardar Sezgin, Hanife
dc.contributor.authorDilgin, Yusuf
dc.contributor.authorGökçel, H. İsmet
dc.date.accessioned2024-12-18T06:19:07Z
dc.date.available2024-12-18T06:19:07Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.description.abstractThis paper describes an application and comparison of two stripping voltammetric methods for the speciation of antimony. These methods are based on the formation of the antimony complexes in the presence of two separate chemical receptors, rivastigmine and hematoxylin, and their accumulation on a glassy carbon electrode. They were utilized for the first time to determine Sb(III) and Sb(V) in meglumine antimonite used in the treatment of leishmaniasis. For this purpose, first, the peak current of Sb(III) for a certain amount of drug sample was separately measured using two different receptors. Then, for the same amount of sample, the peak current of total antimony was separately determined in the presence of each receptor by standard addition method after the reduction of Sb(V) ions to Sb(III) with ʟ-cysteine. The current value of Sb(V) was calculated by subtracting the peak current of Sb(III) from that of total antimony for each addition. Then, the calibration curves for the current values of Sb(V) and total antimony were plotted, and the concentrations of Sb(V) and total antimony were determined. The Sb(III) concentration was calculated from the difference between these two values. The Sb(III) and Sb(V) contents were found 16.99 and 82.93 mg cm−3 in the presence of rivastigmine, and 16.59 and 77.96 mg cm−3 in the presence of hematoxylin, respectively. These results showed that both methods were successfully applied to determine Sb(III) and Sb(V) in meglumine antimonite.en_US
dc.identifier.citationSezgin, H. V., Dilgin, Y., & Gökçel, H. İ. (2021). Speciation of antimony in anti-leishmanial drug using two different chemical receptors and adsorptive anodic stripping voltammetry on glassy carbon electrode. Monatshefte Für Chemie - Chemical Monthly, 152(2), 201–208. https://doi.org/10.1007/s00706-020-02731-1en_US
dc.identifier.doi10.1007/s00706-020-02731-1
dc.identifier.endpage208en_US
dc.identifier.issn0026-9247
dc.identifier.issn1434-4475
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85100957430
dc.identifier.startpage201en_US
dc.identifier.urihttps://doi.org/10.1007/s00706-020-02731-1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/6749
dc.identifier.volume152en_US
dc.identifier.wosWOS:000616919900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDilgin, Yusuf
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofMonatshefte fur Chemieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlucantimeen_US
dc.subjectHematoxylinen_US
dc.subjectMeglumine antimoniateen_US
dc.subjectRivastigmineen_US
dc.titleSpeciation of antimony in anti-leishmanial drug using two different chemical receptors and adsorptive anodic stripping voltammetry on glassy carbon electrode
dc.typeArticle

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