Evaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodies

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dc.authoridALTUN, ARMAGAN/0000-0002-3233-8263
dc.contributor.authorBarutcu, A.
dc.contributor.authorAksu, F.
dc.contributor.authorOzcelik, F.
dc.contributor.authorBarutcu, C. A. E.
dc.contributor.authorUmit, G. E.
dc.contributor.authorPamuk, O. N.
dc.contributor.authorAltun, A.
dc.date.accessioned2025-01-27T21:04:13Z
dc.date.available2025-01-27T21:04:13Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n=50) and control group (n = 30). They were categorized into four subgroups: anticardiolipin antibodies (aCL) (+) (n = 14) and aCL (-) (n = 36); systemic lupus erythematosus disease activity index (SLEDAI) >= 6 (n = 15) and SLEDAI < 6 (n = 35); disease period >= 5 years (n = 21) and disease period < 5 years (n = 29); major organ involvement (+) (n = 19), major organ involvement (-) (n = 31). The ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity (E/E') for the study group was found to be higher than the control (p < 0.01). Systolic septal motion velocity (Ssm) was lower in the study group compared with the control (p < 0.01). Left atrium (LA) dimension was greater in the study group than the control (p < 0.01). Ssm was found to be lower in the aCL (+) patients compared with the control and aCL (-) groups (p < 0.01, p < 0.05, respectively). LA dimension was greater in the aCL (+) and (-) groups compared with the control, (p < 0.01, p < 0.05, respectively) and aCL groups compared with each other (p < 0.05). The E/E' ratio for the aCL (+) and (-) groups was found to be greater than the control (p < 0.05). In the study, both the Ssm and the late diastolic septal velocity (sA') was found to be lower in the SLEDAI >= 6 group compared with SLEDAI < 6 group, (p < 0.001, p < 0.05, respectively). LA dimension was statistically greater in the SLEDAI >= 6 group compared with the SLEDAI < 6 group (p < 0.001). E' and early diastolic septal velocity (sE') were statistically lower in the disease period > 5 years group compared with the disease period < 5 years group (p < 0.01, p < 0.05, respectively). Carrying out regular scans with TTE image of SLE patients is important in order to identify early cardiac involvement during monitoring and treatment. Identifying early cardiac involvement in SLE may lead to a reduction in mortality and morbidity rates.
dc.identifier.doi10.1177/0961203315570164
dc.identifier.endpage1028
dc.identifier.issn0961-2033
dc.identifier.issn1477-0962
dc.identifier.issue10
dc.identifier.pmid25697770
dc.identifier.scopus2-s2.0-84938806824
dc.identifier.scopusqualityQ2
dc.identifier.startpage1019
dc.identifier.urihttps://doi.org/10.1177/0961203315570164
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27585
dc.identifier.volume24
dc.identifier.wosWOS:000359402200002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofLupus
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAnticardiolipin antibody
dc.subjecttissue Doppler
dc.subjectdiastolic dysfunction
dc.subjectsystemic lupus erythematosus
dc.subjectcardiovascular disease
dc.titleEvaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodies
dc.typeArticle

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