Gastroprotective effect of apricot kernel oil in ethanol-induced gastric mucosal injury in rats

Basit Öğe Kaydı
dc.authoridkaraboga, ihsan/0000-0001-6708-1229
dc.authoridYILMAZ, AHSEN/0000-0002-2270-2965
dc.contributor.authorKaraboga, I.
dc.contributor.authorOvali, M. A.
dc.contributor.authorYilmaz, A.
dc.contributor.authorAlpaslan, M.
dc.date.accessioned2025-01-27T20:49:45Z
dc.date.available2025-01-27T20:49:45Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe investigated the gastroprotective effect of apricot kernel oil on ethanol induced gastric ulcer in rats. Male Wistar albino rats were divided into control, ethanol and apricot kernel oil + ethanol groups. The fatty acid composition of apricot kernel oil was determined using GC-MS. A gastric ulcer index was defined as the area percentage of the gastric mucosa consisting of ulcerated tissue. Gastric tissue was investigated by TUNEL staining for apoptosis, immunohistochemical iNOS staining, measurement of gastric IL-10 and IL-6 expression by ELISA and assays of catalase, malondialdehyde and superoxide dismutase. The ethanol group exhibited a higher gastric ulcer score, increased IL-6 level, increased number of inducible nitric oxide synthase-positive and TUNEL positive cells, and a higher MDA level compared to the control group. The apricot kernel oil + ethanol group exhibited significantly fewer gastric lesions compared to the ethanol group. Apricot kernel oil protects rat gastric mucosa against ethanol induced injury by its anti-inflammatory, anti-oxidative and anti-apoptotic effects, and might be useful for reducing the severity of gastric ulcers.
dc.identifier.doi10.1080/10520295.2018.1511064
dc.identifier.endpage607
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue8
dc.identifier.pmid30234391
dc.identifier.scopus2-s2.0-85053541313
dc.identifier.scopusqualityQ2
dc.identifier.startpage601
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1511064
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25304
dc.identifier.volume93
dc.identifier.wosWOS:000451027400008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectApoptosis
dc.subjectapricot kernel
dc.subjectethanol
dc.subjectgastric ulcer
dc.subjectoil
dc.subjectrats
dc.titleGastroprotective effect of apricot kernel oil in ethanol-induced gastric mucosal injury in rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu