Chemically Cross-Linked Poly(?-Cyclodextrin) Particles as Promising Drug Delivery Materials
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Amer Chemical Soc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
One-pot synthesis of poly(β-cyclodextrin) (p(β-CD)) micro-/nanoparticles was accomplished using two different cross-linkers, divinyl sulfone (DVS) as p(β-CD)-1 and trimethylolpropane glycidyl ether (TMPGDE) as p(β-CD)-2. High gravimetric yields of 84 ± 4 and 62 ± 6%, respectively, were attained for p(β-CD)-1 and p(β-CD)-2 particles. The p(β-CD)-1 and p(β-CD)-2 particles had spherical shapes with 5.09 ± 0.24 and 0.60 ± 0.01 μm diameters, respectively, and exhibited good water dispersibility at physiological pH, and their isoelectric points were calculated correspondingly to be pH 1.1 and 1.2. The surface areas of p(β-CD)-1 and p(β-CD)-2 particles were determined to be 4.76 ± 0.6 and 2.18 ± 0.2 m2/g, respectively. Moreover, p(β-CD) particles were found to be biocompatible with more than 98% cell viability on human retinal pigment epithelial (ARPE-19) cells at 0.1 mg/mL concentration. Also, p(β-CD)-1 particles exhibited 52.81 ± 9.5% Fe(II) chelation capacity at 1.0 mg/mL concentration. The hemolysis and coagulation tests revealed that p(β-CD)-1 particles possessed excellent blood compatibility with a 1.18 ± 0.60% hemolysis ratio and a 92.02 ± 1.02% clotting index even at 2.0 mg/mL concentration, whereas the safety limit of p(β-CD)-2 particles for blood interactions was determined to be 0.5 mg/mL. The in vitro drug release performances of p(β-CD)-1 and p(β-CD)-2 particles for hydrophobic acyclovir and hydrophilic vancomycin model drugs at pH 7.4 PBS showed sustained releases of 2.14 ± 0.34 and 1.34 ± 0.43 mg/g acyclovir and 51.90 ± 1.09 and 61.26 ± 3.71 mg/g vancomycin within 24 h, respectively. Kinetic modeling of experimental release data revealed the best fit for drug release from p(β-CD) particles mediated by the Korsmeyer-Peppas model. ©
Açıklama
Anahtar Kelimeler
cross-linker, cyclodextrins, divinyl sulfone, poly(β-Cyclodextrin), polymerization
Kaynak
ACS Applied Polymer Materials
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
3
Sayı
12
Künye
Demirci, S., Khiev, D., Can, M., Sahiner, M., Biswal, M. R., Ayyala, R. S., & Sahiner, N. (2021). Chemically cross-linked poly(β-cyclodextrin) particles as promising drug delivery materials. ACS Applied Polymer Materials, 3(12), 6238-6251. doi:10.1021/acsapm.1c01058
