Association between ABCB1 (MDR1) Gene 3435 C>T Polymorphism and Colchicine Unresponsiveness of FMF Patients

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dc.authoridsilan, coskun/0000-0002-8352-6571
dc.contributor.authorOzen, Filiz
dc.contributor.authorSilan, Coskun
dc.contributor.authorUludag, Ahmet
dc.contributor.authorCandan, Ferhan
dc.contributor.authorSilan, Fatma
dc.contributor.authorOzdemir, Semra
dc.contributor.authorAtik, Sinem
dc.date.accessioned2025-01-27T20:29:39Z
dc.date.available2025-01-27T20:29:39Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in protecting cells from xenobiotics, chemicals, and drugs. The TT genotype of 3435 codon in exon 26 of MDR1 gene causes overexpression of gene activity and effluxes many chemically diverse compounds across the plasma membrane. We studied the association between C3435T polymorphisms (single nucleotide polymorphism) of MDR1 gene and colchicine-resistant familial Mediterranean fever (FMF) patients. Total genomic DNA samples from 52 FMF patients of colchicine unresponsiveness were used for FMF (MEFV) and MDR1 genes profile analyses. Target genes were genotyped by multiplex PCR-based reverse-hybridization Strip Assay method. The preliminary current results showed increased T allele frequency (0.596) in colchicine unresponsiveness of FMF patients. The distributions of the CC, CT, and TT genotypes in colchicine nonresponder FMF patients were 17%, 46%, and 37%, respectively. Our results indicate that C3435T polymorphism in exon 26 of MDR1 gene is associated with colchicine resistance in nonresponder FMF patients during the common therapy protocol.
dc.identifier.doi10.3109/0886022X.2011.605980
dc.identifier.endpage903
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue9
dc.identifier.pmid21851199
dc.identifier.scopus2-s2.0-80053484643
dc.identifier.scopusqualityQ2
dc.identifier.startpage899
dc.identifier.urihttps://doi.org/10.3109/0886022X.2011.605980
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23007
dc.identifier.volume33
dc.identifier.wosWOS:000295339700009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectC3435T polymorphism
dc.subjectcolchicine resistance
dc.subjectFMF
dc.subjectMDR1
dc.titleAssociation between ABCB1 (MDR1) Gene 3435 C>T Polymorphism and Colchicine Unresponsiveness of FMF Patients
dc.typeArticle

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