Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats

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dc.authoridTOKTAY, Erdem/0000-0002-0715-2707
dc.authoridAdali, Yasemen/0000-0002-8004-7364
dc.authoridYayla, Muhammed/0000-0002-0659-3084
dc.contributor.authorYayla, Muhammed
dc.contributor.authorCetin, Damla
dc.contributor.authorAdali, Yasemen
dc.contributor.authorKilicle, Pinar Aksu
dc.contributor.authorToktay, Erdem
dc.date.accessioned2025-01-27T20:41:04Z
dc.date.available2025-01-27T20:41:04Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective(s): The aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats. Materials and Methods: Fifty-six female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Operation, Group 2; Ischemia, Group 3; Ischemia + Reperfusion, Group 4; Ischemia + Pomegranate 0,32 ml / kg (IP), Group 5; Ischemia + Pomegranate 0.64 ml / kg, Group 6; Ischemia + Pomegranate 0,32 ml / kg + reperfusion, Group 7; Ischemia + Pomegranate 0,64 ml / kg + reperfusion. Three hours after ischemia and 3 hours after reperfusion, the study was terminated. Results: While NADPH oxidase activity, MDA and TNF-alpha levels were significantly increased, SOD activity and GSH levels were reduced in ischemia and I/R groups. Low dose pomegranate seed oil application reduced significantly oxidative stress and NADPH oxidase activity in both ischemic and ischemic/reperfusion groups. At the same time, low-dose pomegranate seed oil extract reduced TNF-alpha levels and significantly increased antioxidant activity. Conclusion: PSO demonstrated an important therapeutic effect in the treatment of ovarian ischemia and reperfusion injury.
dc.description.sponsorshipKafkas University [2016TS32]
dc.description.sponsorshipThis work was supported by Kafkas University Scientific Research Project (grant number 2016TS32). A part of this study was presented at international congress by 2nd International Science Symposium (Science Festival) Tiflis, Georgia, 2017. There is no conflict interest and financial disclosure for all author.
dc.identifier.doi10.22038/ijbms.2018.30149.7268
dc.identifier.endpage1268
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue12
dc.identifier.pmid30627370
dc.identifier.scopus2-s2.0-85055647502
dc.identifier.scopusqualityQ2
dc.identifier.startpage1262
dc.identifier.urihttps://doi.org/10.22038/ijbms.2018.30149.7268
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23996
dc.identifier.volume21
dc.identifier.wosWOS:000447926600010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMashhad Univ Med Sciences
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectIschemia/Reperfusion
dc.subjectOxidative stress
dc.subjectOvary
dc.subjectPomegranate seed oil
dc.subjectPunicaceae
dc.subjectRats
dc.titlePotential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats
dc.typeArticle

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