Changes on the Pancreas in Experimental Diabetes and the Effect of Lycopene on These Changes: Pdx-1, Ngn-3, and Nestin Expressions

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dc.authoridKaragenc, Levent/0000-0003-2074-2450
dc.authoridYıldız, Mustafa/0000-0003-4128-8947
dc.authoridSANDIKCI, MUSTAFA/0000-0002-9126-1016
dc.contributor.authorSandikci, Mustafa
dc.contributor.authorKaragenc, Levent
dc.contributor.authorYıldız, Mustafa
dc.date.accessioned2025-01-27T21:00:06Z
dc.date.available2025-01-27T21:00:06Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of the present study was to investigate changes occurring in the number of beta cells, as well as the expressions of Ngn-3, nestin and Pdx-1 of pancreatic progenitor cells in the pancreas of experimentally-induced adult diabetic rats and to determine the effect of orally-administered lycopene on these changes. Following the administration of 50 mg/kg streptozotocin to rats, four groups of animals were established: control+corn oil, control+lycopene, diabetic+corn oil and diabetic+lycopene. The animals in the control+lycopene and diabetic+lycopene groups received 4 mg/kg lycopene for a period of four weeks. The expressions of insulin, Ngn-3, nestin, and Pdx-1 were determined through immunohistochemistry in sections taken from pancreas tissue samples at the end of the experiment. The number of insulin-positive cells was found to be significantly low in the diabetic groups compared to the control groups. In addition, the presence of Ngn-3 and nestin-positive cells within the exocrine pancreas surrounding the islands was noted in the diabetic groups. Lycopene, in general did not have any effect in any of the parameters analyzed in the present study. It is suggested that these cells would function as stem cells to replace the lost beta-cell population. It is also suggested that it is possible to demonstrate the antioxidant effects of lycopene in the pancreas of diabetic rats by increasing the dose and duration of lycopene administration. Anat Rec, 300:2200-2207, 2017. (c) 2017 Wiley Periodicals, Inc.
dc.description.sponsorshipAdnan Menderes University research fund [VTF-13005]
dc.description.sponsorshipGrant sponsor: Adnan Menderes University research fund; Grant number: VTF-13005.
dc.identifier.doi10.1002/ar.23687
dc.identifier.endpage2207
dc.identifier.issn1932-8486
dc.identifier.issn1932-8494
dc.identifier.issue12
dc.identifier.pmid28921917
dc.identifier.scopus2-s2.0-85033388809
dc.identifier.scopusqualityQ1
dc.identifier.startpage2200
dc.identifier.urihttps://doi.org/10.1002/ar.23687
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26938
dc.identifier.volume300
dc.identifier.wosWOS:000414941600012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAnatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectbeta cell
dc.subjectexperimental diabetes
dc.subjectlycopene
dc.subjectpancreas
dc.subjectprogenitor cell
dc.titleChanges on the Pancreas in Experimental Diabetes and the Effect of Lycopene on These Changes: Pdx-1, Ngn-3, and Nestin Expressions
dc.typeArticle

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