Association between FokI, ApaI and TaqI RFLP polymorphisms in VDR gene and Hashimoto's thyroiditis: preliminary data from female patients in Serbia

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dc.authoridVelickovic, Jelena/0000-0002-4834-8044
dc.authoridStojkovic, Oliver/0000-0002-4794-1882
dc.authoridStamenkovic, Gorana/0000-0002-5809-7189
dc.contributor.authorDjurovic, J.
dc.contributor.authorStojkovic, O.
dc.contributor.authorOzdemir, O.
dc.contributor.authorSılan, Fatma
dc.contributor.authorAkurut, C.
dc.contributor.authorTodorovic, J.
dc.contributor.authorSavic, K.
dc.date.accessioned2025-01-27T21:04:22Z
dc.date.available2025-01-27T21:04:22Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder caused by an interaction between genes and environmental triggers. Intrathyroid lymphocytic infiltration may lead to progressive destruction of thyroid tissue and consequently to hypothyroidism. Many studies in different populations have shown association between vitamin D receptor (VDR) gene polymorphisms and various autoimmune diseases, including HT. The study included 44 female patients (mean age +/- standard deviation 38 +/- 5.4) with Hashimoto's thyroiditis and 32 healthy age-matched, sex-matched and geographically matched controls without personal history of autoimmune and endocrine diseases. Genomic DNA was isolated from peripheral blood-EDTA, and the target VDR gene was genotyped by PCR-RFLP technique after VDR-FokI (rs2228570), VDR-ApaI (rs7975232) and VDR-TaqI (rs731236) restriction enzymes digestion. We used spss 20.0 integrated software for data analysis and found a significant difference in the genotype distribution of VDR-FokI polymorphism between patients with HT and controls (P=0.009). For ApaI and TaqI, we observed a higher frequency of variant allele in patients with HT, which was not significantly different compared to control women (P>0.05). The current first and preliminary results identified the association between VDR-FokI gene polymorphism and Hashimoto's thyroiditis in Serbian population. Results need to be supported by further investigations that define haplotype patterns for VDR gene polymorphisms in a larger group of HT patients of both sexes.
dc.description.sponsorshipSerbian Ministry of Education, Science and Technology [OI 175093]
dc.description.sponsorshipThis work was supported by the Serbian Ministry of Education, Science and Technology (Grant OI 175093).
dc.identifier.doi10.1111/iji.12199
dc.identifier.endpage194
dc.identifier.issn1744-3121
dc.identifier.issn1744-313X
dc.identifier.issue3
dc.identifier.pmid25817800
dc.identifier.scopus2-s2.0-84929165968
dc.identifier.scopusqualityQ2
dc.identifier.startpage190
dc.identifier.urihttps://doi.org/10.1111/iji.12199
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27622
dc.identifier.volume42
dc.identifier.wosWOS:000354388300008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Immunogenetics
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectVitamin-D-Receptor
dc.subjectBone-Mineral Density
dc.subjectD Deficiency
dc.subjectDisease
dc.subjectCancer
dc.subjectRisk
dc.subject1,25-Dihydroxyvitamin-D3
dc.subjectEpidemiology
dc.subjectInhibition
dc.titleAssociation between FokI, ApaI and TaqI RFLP polymorphisms in VDR gene and Hashimoto's thyroiditis: preliminary data from female patients in Serbia
dc.typeArticle

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