Decrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance

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dc.authoridAsik, mehmet/0000-0002-0716-0221
dc.authoridUkinc, KUBILAY/0000-0002-4727-7432
dc.contributor.authorAsik, Mehmet
dc.contributor.authorGunes, Fahri
dc.contributor.authorBinnetoglu, Emine
dc.contributor.authorEroglu, Mustafa
dc.contributor.authorBozkurt, Neslihan
dc.contributor.authorSen, Hacer
dc.contributor.authorAkbal, Erdem
dc.date.accessioned2025-01-27T21:02:01Z
dc.date.available2025-01-27T21:02:01Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe aimed to evaluate the prevalence of lactose intolerance (LI) in patients with Hashimoto's thyroiditis (HT) and the effects of lactose restriction on thyroid function in these patients. Eighty-three HT patients taking l-thyroxine (LT4) were enrolled, and lactose tolerance tests were performed on all patients. Lactose intolerance was diagnosed in 75.9 % of the patients with HT. Thirty-eight patients with LI were started on a lactose-restricted diet for 8 weeks. Thirty-eight patients with LI (30 euthyroid and 8 with subclinical hypothyroidism), and 12 patients without LI were included in the final analysis. The level of TSH significantly decreased in the euthyroid and subclinical hypothyroid patients with LI [from 2.06 +/- A 1.02 to 1.51 +/- A 1.1 IU/mL and from 5.45 +/- A 0.74 to 2.25 +/- A 1.88 IU/mL, respectively (both P < 0.05)]. However, the level of TSH in patients without LI did not change significantly over the 8 weeks (P > 0.05). Lactose intolerance occurs at a high frequency in HT patients. Lactose restriction leads to decreased levels of TSH, and LI should be considered in hypothyroid patients who require increasing LT4 doses, have irregular TSH levels and are resistant to LT4 treatment.
dc.identifier.doi10.1007/s12020-013-0065-1
dc.identifier.endpage284
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue2
dc.identifier.pmid24078411
dc.identifier.scopus2-s2.0-84902290286
dc.identifier.scopusqualityQ2
dc.identifier.startpage279
dc.identifier.urihttps://doi.org/10.1007/s12020-013-0065-1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27257
dc.identifier.volume46
dc.identifier.wosWOS:000336977400017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEndocrine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectLactose intolerance
dc.subjectHashimoto's thyroiditis
dc.subjectHypothyroidism
dc.subjectL-Thyroxine malabsorption
dc.titleDecrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance
dc.typeArticle

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