Asprosin, a C-Terminal Cleavage Product of Fibrillin 1 Encoded by the FBN1 Gene, in Health and Disease

Basit Öğe Kaydı
dc.authoridbozgeyik, ibrahim/0000-0003-1483-2580
dc.contributor.authorOvali, Mehmet Akif
dc.contributor.authorBozgeyik, Ibrahim
dc.date.accessioned2025-01-27T20:43:55Z
dc.date.available2025-01-27T20:43:55Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Asprosin is a novel fasting-induced, glucogenic, and orexigenic protein hormone that is discovered with the help of genetic studies in patients with neonatal progeroid syndrome. Asprosin is encoded by the penultimate 2 exons (65 and 66) of the fibrillin 1 (FBN1) gene. Profibrillin 1 is the unprocessed protein product of FBN1 and undergoes a proteolytic cleavage by furin enzyme to produce mature fibrillin 1 and asprosin. The main organ responsible for the asprosin production seems to be white adipose tissue. Summary: Asprosin promotes hepatic glucose release in the liver and appetite stimulation in the hypothalamus through activation of the cAMP signaling circuitry through interacting with its G protein-coupled receptor, called OR4M1. Increasing mass of evidence suggests that asprosin is involved in the development and progression of various clinical conditions including diabetes, obesity, cardiomyopathy, cancer, and polycystic ovarian syndrome. It regulates various cellular and physiological processes such as appetite stimulation, glucose release, insulin secretion, apoptotic cell death, and inflammatory response. In this review, we discuss the current literature on asprosin and try to shed light on the yet undiscovered functions of asprosin. Key Message: Asprosin is a key regulatory factor for preserving the homeostasis of energy metabolism.
dc.identifier.doi10.1159/000520333
dc.identifier.endpage183
dc.identifier.issn1661-8769
dc.identifier.issn1661-8777
dc.identifier.issue3
dc.identifier.pmid35707591
dc.identifier.scopus2-s2.0-85124889381
dc.identifier.scopusqualityQ4
dc.identifier.startpage175
dc.identifier.urihttps://doi.org/10.1159/000520333
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24422
dc.identifier.volume13
dc.identifier.wosWOS:000753768400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofMolecular Syndromology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAsprosin
dc.subjectFBN1
dc.subjectMarfan syndrome
dc.subjectNeonatal progeroid syndrome
dc.subjectFibrillin 1
dc.titleAsprosin, a C-Terminal Cleavage Product of Fibrillin 1 Encoded by the FBN1 Gene, in Health and Disease
dc.typeReview Article

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu