Comparison of SUVmax values obtained from F-18 FDG PET/CT and cell-free DNA levels measured from plasma in oncology patients

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dc.contributor.authorÇelik, Fatmanur
dc.contributor.authorTan, Yusuf Ziya
dc.contributor.authorÖzdemir, Semra
dc.contributor.authorSılan, Fatma
dc.date.accessioned2025-01-27T19:00:39Z
dc.date.available2025-01-27T19:00:39Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: The aim of this study was to compare the quantitative value of standardized uptake value (SUV) SUVmax obtained from F-18 FDG positron emission tomography/computed tomography (PET/CT) imaging of oncology patients with the cell-free DNA (cfDNA) amounts measured in plasma of patients and thus investigate if cfDNA is a significant marker to identify the presence of malignancy in the early period. Methods: A total of 184 patients were included in the study. The clinical, histopathologic, laboratory and treatment parameters were extracted from patient files. SUVmax and cfDNA quantities were assessed. Results: There was no statistically significant difference in plasma cfDNA values between patient and control groups. The comparison of SUVmax and cfDNA values in the study showed that there was a weak correlation between SUVmax and cfDNA. There was a significant difference between tumor size and SUVmax values. However, there was no statistically significant difference between tumor size and cfDNA. Conclusion: cfDNA measurements in the blood as a screening test have provided hope for early diagnosis and monitoring of cancer patients. Comparison of cfDNA levels obtained from plasma and quantitative parameters from PET/CT images of oncology patients in detailed advanced studies with larger patient series are required. © 2019 by Turkish Society of Nuclear Medicine Molecular Imaging and Radionuclide Therapy published by Galenos Yayınevi.
dc.description.sponsorshipÇanakkale University, (TTU-2014-390)
dc.identifier.doi10.4274/mirt.galenos.2019.60352
dc.identifier.endpage52
dc.identifier.issn2146-1414
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85071149367
dc.identifier.scopusqualityQ3
dc.identifier.startpage46
dc.identifier.trdizinid368591
dc.identifier.urihttps://doi.org/10.4274/mirt.galenos.2019.60352
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/368591
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13417
dc.identifier.volume28
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos
dc.relation.ispartofMolecular Imaging and Radionuclide Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250125
dc.subjectCell-free DNA; F-18 FDG PET/CT; SUV<sub>max</sub>
dc.titleComparison of SUVmax values obtained from F-18 FDG PET/CT and cell-free DNA levels measured from plasma in oncology patients
dc.title.alternativeOnkoloji hastalarında F-18 FDG PET/BT’de elde edilen SUVmaks değerleri ile plazmadan ölçülen cell-free DNA seviyelerinin karşılaştırılması
dc.typeArticle

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