Poisoning severity score, Glasgow coma scale, corrected QT interval in acute organophosphate poisoning

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dc.authoridAKDUR, OKHAN/0000-0003-3099-6876
dc.authoridOzkan, Seda/0000-0003-1835-8820
dc.authoridIKIZCELI, IBRAHIM/0000-0002-9825-4716
dc.authoridkavalci, cemil/0000-0003-2529-2946
dc.contributor.authorAkdur, Okhan
dc.contributor.authorDurukan, Polat
dc.contributor.authorOzkan, Seda
dc.contributor.authorAvsarogullari, Levent
dc.contributor.authorVardar, Alper
dc.contributor.authorKavalci, Cemil
dc.contributor.authorIkizceli, Ibrahim
dc.date.accessioned2025-01-27T20:53:50Z
dc.date.available2025-01-27T20:53:50Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of this study was to investigate effectiveness of the poisoning severity score (PSS), Glasgow coma scale (GCS), and corrected QT (QTc) interval in predicting outcomes in acute organophosphates (OP) poisoning. Over a period of 2 years, 62 patients with OP poisoning were admitted to emergency department (ED) of Erciyes University Medical School Hospital. The age, sex, cause of contact, compound involved, time elapsed between exposure and admission to the ED, duration of hospital stay, and cardiac manifestations at the time of presentation were recorded. GCS and poisoning severity score (PSS) was calculated for each patient. Electrocardiogram (ECG) analysis included the rate, rhythm, ST-T abnormalities, conduction defects, and measurement of PR and QT intervals. Sixty-two patients with OP poisoning presented to our ED from January 2007 to December 2008 from which 54 patients were included in the study. The mean age was 34.1 +/- 14.8 years. Of the cases, 53.7% were female. Twenty-six patients had a prolonged QTc interval. Mean PSS of men and women was 1.8 +/- 1.0. No statistically significant correlation was found between the PSS and QTc intervals of the cases. A significant correlation was determined between the GCS and PSS of grade 3 and grade 4 cases. GCS is a parameter that helps clinician to identify advanced grade OP poisoning patients in the initial assessment in the ED. However, ECG findings, such as prolonged QTc interval, are not effective in determination of short-term prognosis and show no relationship with PSS.
dc.identifier.doi10.1177/0960327110364640
dc.identifier.endpage425
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue5
dc.identifier.pmid20203133
dc.identifier.scopus2-s2.0-77951149880
dc.identifier.scopusqualityQ2
dc.identifier.startpage419
dc.identifier.urihttps://doi.org/10.1177/0960327110364640
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25860
dc.identifier.volume29
dc.identifier.wosWOS:000276552600009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofHuman & Experimental Toxicology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectclinical toxicology
dc.subjectorganophosphates
dc.subjectpoisoning
dc.titlePoisoning severity score, Glasgow coma scale, corrected QT interval in acute organophosphate poisoning
dc.typeArticle

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