Effect of glucocorticoids on nasal polyposis, with detection of inflammatory response by measurement of nitric oxide levels in nasal polyp tissue

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dc.contributor.authorBulbul, T.
dc.contributor.authorBulbul, O. Gumustekin
dc.contributor.authorGuclu, O.
dc.contributor.authorBilsel, A. Serpil
dc.contributor.authorGursan, S. Onal
dc.date.accessioned2025-01-27T21:00:07Z
dc.date.available2025-01-27T21:00:07Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To investigate endoscopic staging, and nitric oxide levels in the polyp tissue, in patients with nasal polyposis undergoing glucocorticoid therapy. Methods: Nasal polyposis was evaluated using endoscopic staging and measurement of polyp tissue nitric oxide levels (chemiluminescence method). Forty-five nasal polyposis patients received either nasal therapy (n = 15), oral therapy (n = 15) or combined therapy (n = 15). Pre-treatment and post-treatment staging and nitric oxide levels were evaluated. Results: Endoscopic grading indicated significant post-treatment staging improvements in the oral (p = 0.016) and combined (p = 0.016) groups. Post-treatment staging differed significantly between the three groups (p = 0.041), with greater improvements in the oral and combined groups. All groups showed significantly lower post-treatment nitric oxide levels, compared with baseline, but post-treatment levels did not differ significantly between groups. A significant association was found between treatment response and nitric oxide level alteration. Conclusion: This study demonstrates the favourable effects of glucocorticoids on nasal polyposis, and alteration in nitric oxide tissue levels post-treatment. Nitric oxide level in nasal polyp tissue could be an indicator of treatment response, and may aid surgical decision-making by detecting cases that probably will not respond to medical treatment.
dc.identifier.doi10.1017/S002221511300073X
dc.identifier.endpage589
dc.identifier.issn0022-2151
dc.identifier.issn1748-5460
dc.identifier.issue6
dc.identifier.pmid23587256
dc.identifier.scopus2-s2.0-84878796788
dc.identifier.scopusqualityQ2
dc.identifier.startpage584
dc.identifier.urihttps://doi.org/10.1017/S002221511300073X
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26941
dc.identifier.volume127
dc.identifier.wosWOS:000319877800011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCambridge Univ Press
dc.relation.ispartofJournal of Laryngology and Otology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectNasal Polyps
dc.subjectNitric Oxide
dc.subjectGlucocorticoids
dc.subjectCorticosteroids
dc.subjectChemiluminescence
dc.titleEffect of glucocorticoids on nasal polyposis, with detection of inflammatory response by measurement of nitric oxide levels in nasal polyp tissue
dc.typeArticle

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