Polyphenols as Antiviral Agents: Their Potential Against a Range of Virus Types

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dc.authorid0009-0001-7149-922X
dc.authorid0000-0002-2913-2846
dc.authorid0000-0003-4566-8015
dc.contributor.authorCoskun, Nurten
dc.contributor.authorDemir, Ranya
dc.contributor.authorCanbolat, Ahmet Alperen
dc.contributor.authorSaritas, Sumeyye
dc.contributor.authorPekdemir, Burcu
dc.contributor.authorBechelany, Mikhael
dc.contributor.authorKarav, Sercan
dc.date.accessioned2026-02-03T11:59:50Z
dc.date.available2026-02-03T11:59:50Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPolyphenols are structurally diverse plant metabolites that have attracted significant interest. Their compositions are versatile, depending on their structures, including the number of rings in the polyphenol composition. Based on these attributes, polyphenols can be classified as flavanols, anthocyanins, flavones, phenolic acids, stilbenes, and lignans. Polyphenols mainly possess inhibition of viral replication, interference with viral protein synthesis, and modulation of immune responses, providing significant antiviral effects against several viruses, including herpes simplex virus, hepatitis C virus, and influenza. They are crucial for medical compounds in diverse, versatile treatments, namely in diabetes, cardiovascular disorders, cancer, and neurodegenerative problems. Plants are the primary source of bioactive molecules, which are valued for their anti-inflammatory, antioxidant, anticancer, and antiviral activities. Especially, polyphenols are extracted as the most abundant bioactive compounds of plants. Moreover, viral infections are one of the major factors in illnesses and diseases, along with bacteria and fungi. Numerous in vitro and in vivo studies report antiviral activity against SARS-CoV-2, Mayaro virus, dengue virus, herpesvirus, and influenza A virus, though clinical validation remains limited. Additionally, inhibition of viral entry, interference with viral replication, modulation of host immune response, and direct virucidal effects were examined.
dc.identifier.doi10.3390/nu17142325
dc.identifier.issn2072-6643
dc.identifier.issue14
dc.identifier.pmid40732950
dc.identifier.scopus2-s2.0-105011607930
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/nu17142325
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34438
dc.identifier.volume17
dc.identifier.wosWOS:001535605900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofNutrients
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectpolyphenols
dc.subjectantiviral effect
dc.subjectviral diseases
dc.titlePolyphenols as Antiviral Agents: Their Potential Against a Range of Virus Types
dc.typeReview

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