Effects of sub-MIC antibiotic concentrations on biofilm production of Salmonella Infantis

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dc.authoridakcelik, Nefise/0000-0001-5541-1681
dc.authoridOZDEMIR, Fatma Neslihan/0000-0003-4910-5156
dc.contributor.authorTezel, Basar Uymaz
dc.contributor.authorAkcelik, Nefise
dc.contributor.authorYuksel, Fatma Neslihan
dc.contributor.authorKaratug, Neslihan Taskale
dc.contributor.authorAkcelik, Mustafa
dc.date.accessioned2025-01-27T20:54:08Z
dc.date.available2025-01-27T20:54:08Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn the present study, 13 Salmonella Infantis strains, which have been originated from Turkey, were selected due to their clinical and industrial relevance, sufficient biofilm producing capability and multidrug resistance. Although all tested strains were built up of thin pellicle, optimum pellicle formation has occurred at 28 degrees C. All S. Infantis biofilms were categorized as bdar' morphotype following the incubation at both 20 and 28 degrees C, while they were categorized as saw' morphotype at 37 degrees C. Under a certain incubation temperature (28 degrees C), 84.62% of strains have formed strong biofilm structures. By using the disk diffusion method, high levels of resistance have been observed among tested bacteria against nalidixic acid (100%), spectinomycin (100%), streptomycin (92.3%), tetracycline (92.3%), kanamycin (76.9%) and neomycin (76.9%). Further studies were performed with S. Infantis DMC 12 strain, due to its capability to produce biofilm and multidrug resistance phenotype. Gentamycin (>64 mu g/mL, 2x MIC) and tetracycline (>128 mu g/mL, 4x MIC) were determined as the most effective antibiotics against biofilm formation. The biofilm forms have showed increased antimicrobial resistance when it was compared to the planktonic bacteria. The highest resistance rates of the biofilm bacteria were observed to neomycin (12x MIC) followed by spectinomycin (10x MIC) and streptomycin (10x MIC). Biofilm structure was induced as a result of nalidixic acid, spectinomycin, tetracycline and neomycin treatment at sub-MIC concentrations of tested antibiotics.
dc.identifier.doi10.1080/13102818.2016.1224981
dc.identifier.endpage1191
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue6
dc.identifier.scopus2-s2.0-84987905129
dc.identifier.scopusqualityQ3
dc.identifier.startpage1184
dc.identifier.urihttps://doi.org/10.1080/13102818.2016.1224981
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25984
dc.identifier.volume30
dc.identifier.wosWOS:000387443800020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSalmonella Infantis
dc.subjectantibiotic resistance
dc.subjectbiofilm
dc.subjectinduction
dc.subjectMIC
dc.subjectsub-MIC
dc.titleEffects of sub-MIC antibiotic concentrations on biofilm production of Salmonella Infantis
dc.typeArticle

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