Serum Pentraxin 3 Concentration in Neonatal Sepsis

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dc.authoridAylanc, Hakan/0000-0002-8907-3809
dc.authoridBulut, Ozgul/0000-0001-9939-7375
dc.contributor.authorBattal, Fatih
dc.contributor.authorBulut, Ozgul Emel
dc.contributor.authorYildirim, Sule
dc.contributor.authorAylanc, Hakan
dc.contributor.authorKaymaz, Nazan
dc.contributor.authorUysal, Sema
dc.date.accessioned2025-01-27T20:23:13Z
dc.date.available2025-01-27T20:23:13Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective Neonatal sepsis is one of the most important causes of neonatal morbidity and mortality. Symptoms and signs of neonatal sepsis can be silent; therefore, laboratory investigation is necessary in cases of doubt or if there are risk factors. Early diagnosis is important for early intervention and treatment. The most valuable method for diagnosis is blood culture; however, false positivity due to contamination or false negativity despite ongoing fatal bacterial infections can be seen. Pentraxin 3 is a prototype of the long pentraxin family. It has some differences from C-reactive protein (CRP) in terms of gene organization and localization and production site. It is effective in the early phase of inflammation and it is detected as an early marker of sepsis in adults. The aim of this study was to investigate whether pentraxin 3 can be used as a marker in neonatal sepsis. Materials and Methods Thirty newborns with suspected sepsis with antenatal history or the presence of clinical signs of sepsis, such as hypo/hyperthermia, feed intolerance, lethargy, hypotonia, irregular cardiac rhythms, bradycardia, cyanosis, apnea, respiratory distress, or metabolic acidosis, were enrolled in the study as a case group, and 28 healthy newborns were included as a control group. Serum pentraxin 3, procalcitonin, CRP, and hemogram in the study group and serum procalcitonin and pentraxin in the control group were examined. Results Serum pentraxin 3 (pg/mL) and serum procalcitonin (ng/mL) levels were 2,273.82 +/- 1,260.75 and 0.86 +/- 0.52 in the case group and 957.41 +/- 268.00 and 0.19 +/- 0.18 in the control group ( p < 0.001 for both), respectively. Conclusion The present study showed that serum pentraxin 3 levels may be a useful marker in the diagnosis of neonatal sepsis.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University [543]
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University. Project number 543.
dc.identifier.doi10.1055/s-0039-1688930
dc.identifier.endpage222
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85073115392
dc.identifier.scopusqualityQ4
dc.identifier.startpage219
dc.identifier.urihttps://doi.org/10.1055/s-0039-1688930
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22150
dc.identifier.volume14
dc.identifier.wosWOS:000488815700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofJournal of Pediatric Infectious Diseases
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectneonatal sepsis
dc.subjectCRP
dc.subjectprocalcitonin
dc.subjectpentraxin 3
dc.titleSerum Pentraxin 3 Concentration in Neonatal Sepsis
dc.typeArticle

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